原发性干燥综合征合并肺动脉高压80例临床观察

Clinical analysis of 80 cases of primary Sjogren's syndrome with pulmonary arterial hypertension

探讨原发性干燥综合征合并肺动脉高压(pSS-PAH)的危险因素,以便早期诊治该类疾病。选取438例原发性干燥综合征(pSS)患者,依据心脏彩超检测的肺动脉压力进行分组,比较两组临床及实验室指标。438例患者中80例有肺动脉高压(PAH),发生率为18.3%,年龄22~77(59.9±13.8)岁,肺动脉压力在5.33~15.19 kPa之间。多因素Logistic回归分析提示间质性肺炎、年龄、以肺部表现为首发症状是pSS-PAH的危险因素,有这些情况存在时应尽早行超声心动图等检查,早期诊治以改善患者的预后。

To investigate the risk factors of primary Sjogren's syndrome with pulmonary arterial hypertension(pSSPAH)for early diagnosis and treatment,a total of 438 patients with primary Sjogren's syndrome(pSS)were selected.Patients were divided into two groups according to pulmonary arterial pressure detected by cardiac ultrasonography.The clinical and laboratory characteristics between the two groups were compared.Among 438 patients,80 had PAH,the incidence rate was 18.3%.Age of pSS-PAH was 22~77(59.9±13.8)years old,and pulmonary arterial pressure was between 5.33~15.19 kPa.Multivariate logistic regression analysis suggested that interstitial pneumonia,age,and initial pulmonary symptoms were the risk factors for pSS-PAH.In these cases,cardiac ultrasonography should be performed as soon as possible,early diagnosis and treatment can improve the prognosis of patients.