乳腺癌超声造影边缘带增强特征及定量参数与其免疫组化指标的相关性分析

Correlation analysis of marginal zone enhancement features and quantitative parameters of contrast-enhanced ultrasound and immunochemical indexes of breast cancer

目的分析乳腺癌超声造影边缘带增强特征及定量参数与其免疫组化指标的相关性。方法选取经术后病理及免疫组化证实的乳腺癌女性患者76例(76个病灶),均行超声造影检查,观察乳腺癌病灶边缘带增强特征,获取时间-强度曲线(TIC)的定量参数,包括峰值强度、基础强度、梯度、上升支斜率、达峰时间、曲线下面积,分析乳腺癌超声造影特征及定量参数与免疫组化指标雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体-2(HER-2)、增殖细胞核抗原(Ki-67)的相关性。结果乳腺癌病灶超声造影边缘带放射状增强与ER、Ki-67阳性表达相关,穿支增强与HER-2阳性表达相关,造影后范围扩大与ER、HER-2、Ki-67阳性表达相关,边缘增强特征与Ki-67阳性表达相关,差异均有统计学意义(均P<0.05)。乳腺癌超声造影边缘带定量参数峰值强度、TIC曲线下面积及梯度与Ki-67阳性表达均呈正相关,达峰时间与ER、PR阳性表达均呈负相关,差异均有统计学意义(均P<0.05)。结论乳腺癌超声造影边缘带增强特征及定量参数与ER、PR、HER-2、Ki-67具有一定的相关性,可为乳腺癌患者术前选择精准的治疗方式提供一定的参考依据。

Objective To explore the correlation between marginal zone enhancement features and quantitative parameters of contrast-enhanced ultrasound and immunochemical indexes of breast cancer.Methods A total of 76 female breast cancer patients(76 lesions)confirmed by postoperative pathology and immunohistochemistry were selected.All patients underwent contrast-enhanced ultrasonography to observe the enhancement characteristics of the marginal zone of breast cancer lesions,and obtain quantitative parameters of time-intensity curve(TIC)including peak intensity,basic intensity,gradient,ascending branch slope,peak time and area under the curve.The correlation of contrast-enhanced ultrasound parameters and quantitative parameters of contrast-enhanced ultrasound and immunochemical indexes such as estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor-2(HER-2),and proliferating cell nuclear antigen(Ki-67)were analyzed.Results The enhancement of the marginal zone of breast ultrasound lesion was correlated with ER and Ki-67 positive expression.Perforator enhancement was correlated with HER-2 positive expression.The range enlargement after angiography were correlated with the positive expressions of ER,HER-2 and Ki-67,edge enhancement was correlated with Ki-67 positive expression,and the differences were statistically significant(all P<0.05).The peak intensity,the area under the TIC curve and the gradient were positively correlated with the positive expression of Ki-67.The peak time was negatively correlated with the positive expression of ER and PR,and the differences were statistically significant(all P<0.05).Conclusion The marginal zone contrast enhancement features and quantitative parameters of contrast-enhanced ultrasound of breast cancer has certain correlation with ER,PR,HER-2 and Ki-67,which can provide a reference for the selection of preoperative precise treatment methods for breast cancer patients.