基于秀丽隐杆线虫的真菌毒素毒性评价研究进展

Research Progress of Mycotoxin Toxicity Evaluation Based on Caenorhabditis elegans

由于作用范围广、毒性大和时间长等特征,食品中真菌毒素研究受到广泛关注。应用秀丽隐杆线虫(Caenorhabditis elegans)进行毒理学评价具有成本低、易观察、周期短、信号转导途径高度保守等优点而广泛应用到毒理学研究领域,在真菌毒素的毒性评价方面也得到快速发展。该文介绍秀丽隐杆线虫评价真菌毒素的指标及其研究进展,重点关注秀丽隐杆线虫评价真菌毒素毒性的致死率、个体发育与运动行为和生殖能力与寿命等指标。真菌毒素对于胰岛素/类胰岛素生长因子-1(insulin/insulin-like growth factory-1,IIS)、细胞程序性死亡(programmed cell death,PCD)、转化生长因子β(transforming growth factorβ,TGF-β)、丝裂原激活的蛋白激酶(mitogen activated protein kinases,MAPK)4种先天免疫信号通路的影响的研究进展,为进一步基于秀丽隐杆线虫真菌毒素的研究提供理论依据。

Mycotoxin has attracted extensive attention in scientific research due to its wide range of effects,toxicity and long duration of action.As a model organism,C.elegans has the advantages of low cost,easy observation,short cycle,and highly conserved signal transduction pathway.The toxicity evaluation of C.elegans as a model organism for mycotoxins has been rapidly developed.This article focused on the common types of mycotoxins and their hazards and the evaluation of lethality,somatic and motor behavior,reproductive capacity and longevity indicators of mycotoxins by Caenorhabditis elegans and its research progress.It also introduced nematodes in insulin/insulin-like growth factor-1(IIS),programmed cell death(PCD),transforming growth factor β(TGF-β)and mitogen activated protein kinases(MAPK),four innate immune signaling pathways.It provided a theoretical basis for further research based on the mycotoxin of C.elegans.