甲状腺功能亢进症患者生长激素-胰岛素样生长因子-1轴及抗氧化能力指标的研究

Study on the GH-IGF-1 and antioxidant capacity indicators in patients with hyperthyroidism

目的研究甲状腺功能亢进症患者生长激素(GH)-胰岛素样生长因子-1(IGF-1)轴及抗氧化能力。方法选取2016年3月—2017年3月中国人民解放军联勤保障部队天津康复疗养中心收治的甲状腺功能亢进患者236例作为研究组,同时选取在该院体检的200例只伴有碘摄入过量的人群(碘摄入过量组)和正常人群236例(对照组)。比较3组受试者外周血游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、GH、IGF-1、胰岛素(Ins)、丙二醛(MDA)、谷肌甘肽过氧化物酶(GPX)和超氧化物歧化酶(SOD)。结果与对照组比较,碘摄入过量组和研究组的FT3、FT4、GH、IGF-1、Ins和MDA水平均升高(P<0.05),TSH、GPX和SOD水平均降低(P<0.05),与碘摄入过量组比较,研究组的FT3、FT4、GH、IGF-1、Ins、MDA水平均升高(P<0.05),TSH、GPX和SOD水平均降低(P<0.05)。结论甲状腺功能亢进症患者GH-IGF-1轴平衡被破坏,GH、IGF-1水平升高,抗氧化能力降低,碘摄入量增加可能参与损害甲状腺功能的过程,影响GH-IGF-1轴平衡及抗氧化能力。

Objective To investigate the effects of growth hormone-insulin-like growth factor-1(GHIGF-1)and antioxidant capacity indicators in patients with hyperthyroidism.Methods A total of 236 patients with hyperthyroidism admitted to our hospital from March 2016 to March 2017 were enrolled as the study group at the same time,200 iodine excessive intake patients were collected into the odine excessive intake group and 236 healthy volunteers were the control group.The free triiodothyronine(FT3),free thyroxine(FT4),thyrotrophin(TSH),growth hormone(GH),Insulin-like growth factor-1(IGF-1),insulin(insulin,Ins),malonaldehyde(MDA),glutathione peroxidase(GPX)and superoxide dismutase(SOD)were detected among 3 groups.Results Compared with the control group,the levels of FT3,FT4,GH,IGF-1,Ins and MDA in the iodine intake group and the study group were increased(P<0.05),and the levels of TSH,GPX and SOD were decreased(P<0.05).Compared with the iodine intake group,the levels of FT3,FT4,GH,IGF-1,Ins,and MDA in the study group were increased(P<0.05),and the levels of TSH,GPX,and SOD were decreased(P<0.05).Conclusion The GH-IGF-1 is destroyed in patients with hyperthyroidism,the levels of GH and IGF-1 are significantly increased,the antioxidant capacity is decreased,and the excessive iodine intake may be involved in the process of damaging thyroid function,affecting GH-IGF-1 and antioxidant capacity.