阿托品眼用凝胶对睫状环阻塞性青光眼患者视力和眼压的影响

Effect of atropine ophthalmic gel on visual acuity and intraocular pressure in patients with ciliary ring obstructive glaucoma

目的探讨阿托品眼用凝胶与复方托品酰胺滴眼剂对睫状环阻塞性青光眼患者视力和眼压的影响。方法选取2016年1月—2018年1月嘉兴市第一医院收治的睫状环阻塞性青光眼患者68例(68眼),根据不同治疗方式分为观察组与对照组。两组均为34例(34眼)。两组患者均行晶状体超声乳化术治疗,观察组患者采用阿托品眼用凝胶,对照组患者采用复方托品酰胺滴眼剂,比较两组患者的视力和眼压。结果观察组患者治疗后的眼压低于对照组,前房深度长于对照组(P<0.05)。观察组治疗后的裸眼视力、最佳矫正视力高于对照组(P<0.05)。观察组患者治疗后的维生素B12(VB12)、各向异性分数(FA)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)水平高于对照组(P<0.05)。结论采用阿托品眼用凝胶散瞳能够提高睫状环阻塞性青光眼患者晶状体超声乳化术的手术成功率,降低患者的眼压,改善患者的视力水平,疗效确切,值得推荐。

Objective To investigate the effects of atropine ophthalmic gel and compound tropamide eye drops on visual acuity and intraocular pressure in patients with malignant glaucoma.Methods Sixty eight patients(68 eyes)with malignant primary glaucoma admitted to our hospital from January 2016 to January 2018 were enrolled.According to different treatment methods,they were divided into observation group and control group.There were 34 cases(34 eyes)in both groups patient.The patients in both groups underwent phacoemulsification.The patients in the observation group were treated with atropine ophthalmic gel.The patients in the control group were treated with compound tropamide eye drops to compare the visual acuity and intraocular pressure of the two groups.Results The IOP after treatment in the observation group was lower than that in the control group,the anterior chamber depth was higher than that in the control group,and the difference was statistically significant(P<0.05).The naked eye vision and best corrected visual acuity of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).Patients in the observation group had higher vitamin B12(VB12),anisotropy score(FA),interleukin-2(IL-2),and interleukin-6(IL-6)than the control group after treatment,and the differences were statistically significant(P<0.05).Conclusion The use of atropine ophthalmic gel can improve the success rate of phacoemulsification of patients with ciliary ring obstructive glaucoma,reduce the intraocular pressure of the patient,improve the patient’s visual acuity,and the effect is definite.