GSK3β基因3’-UTR多态性与缺血性脑卒中的关系

The association between 3’-UTR polymorphism of GSK3beta gene and ischemic stroke

目的探讨糖原合成酶激酶3β(GSK3β)基因3’-UTR多态性与缺血性脑卒中的关系。方法选择本院2017年3月-2019年3月收治的缺血性脑卒中患者91例作为研究组;另选择本院2017年3月-2019年3月体检健康者80例作为对照组;采用PCR法检测GSK3β基因3’-UTR多态性位点rs334558和rs6438552等位基因和基因型频率。结果研究组ADL评分和认知功能障碍发生率高于对照组(P<0.05);研究组基因位点rs334558等位基因C分布和基因型频率CC高于对照组(P<0.05);研究组基因位点rs6438552等位基因C分布和基因型频率CC高于对照组(P<0.05)。结论GSK3β基因3’-UTR多态性与缺血性卒中存在关系;rs334558和rs6438552位点C等位基因可能为缺血性脑卒中的易感基因。

Objective To investigate the association between glycogen synthase kinase 3 beta(GSK3 beta)gene 3’-UTR polymorphism and ischemic stroke.Methods The 91 patients with ischemic stroke admitted to our hospital from March 2017 to March 2019 were selected as the study group,and 80 healthy people from March 2017 to March 2019 were selected as the control group.The allele and genotype frequencies of 3’-UTR polymorphism loci rs334558 and rs6438552 of GSK3 beta gene were detected by PCR.Results The ADL score of the study group was higher than that of the control group,and the incidence of cognitive impairment was lower than that of the control group(P<0.05).The distribution of rs334558 allele C in the study group was higher than that in the control group,and the genotype frequency CC was higher than that in the control group(P<0.05).The distribution of rs6438552 allele C in the study group was higher than that in the control group,and the genotype frequency CC was higher than that in the control group(P<0.05).Conclusion The 3’-UTR polymorphism of GSK3 beta gene was correlated with ischemic stroke.It was suggested that the C alleles at rs334558 and rs6438552 loci might be susceptible to ischemic stroke.