卡巴拉汀联合左旋多巴对帕金森病患者脑电图及多巴胺转运体的影响

The effects of rivastigmine combined with levodopa on EEG and dopamine transporter in Parkinson’s patients

目的探讨卡巴拉汀联合左旋多巴对帕金森病(PD)患者脑电图及多巴转运体(DAT)的影响。方法将2017年4月-2019年3月在本院就诊的110例帕金森病患者纳入研究,按照随机双盲法分为对照组(55例)和联合组(55例);对照组采用单药治疗,口服左旋多巴片,联合组采用卡巴拉汀联合左旋多巴治疗;比较2组临床疗效、脑电图、多巴转运体活性、PD严重程度、平衡能力等。结果联合组治疗总有效率较对照组高(94.55%VS 81.82%)(P<0.05)。治疗12周后联合组δ、θ频段相对功率谱平均值、PD评定量表(UP-DRS)评分均较对照组低;β1、β2频段相对功率谱平均值、Berg平衡功能量表评分均较对照组高(P<0.05);联合组患侧、健侧DAT活性较对照组高(P<0.05)。2组不良反应总发生率比较无明显差异(P>0.05)。结论卡巴拉汀联合左旋多巴治疗帕金森病患者的疗效确切,可有效缓解病情,改善平衡能力,并可促使脑电图趋于正常,延缓DAT活性下降。

Objective To investigate the effects of rivastigmine combined with levodopa on electroencephalogram and dopamine transporter of patients with Parkinson’s disease(PD).Methods 110 patients with Parkinson’s disease who were admitted to our hospital from April 2017 to March 2019 were enrolled in the study. They were divided into control group(55 cases) and combination group(55 cases) according to random double-blind method. The control group received monotherapy, oral levodopa tablets and the combination group was treated with rivastigmine plus levodopa. The clinical efficacy, electroencephalogram, dopa transporter(DAT) activity, PD severity, and balance ability were compared between the two groups.Results The total effective rate of the combined group was higher than that of the control group(94.55% vs 81.82%)(P<0.05). After treatment, the relative power spectrum average and PD-rated(UP-DRS) scores of the combined group were lower than those of the control group. The average power spectrum of the β1 and β2 bands and the Berg balance function scale were higher than those of the control group(P<0.05). The DAT activity of the affected side and the healthy side of the combined group was higher than those of the control group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of rivastigmine combined with levodopa in the treatment of Parkinson’s patients was effective, could effectively alleviate the disease, improve the balance ability, and could promote the EEG to normal, delay the decline of DAT activity.