中国老年性皮肤瘙痒症患病率的Meta分析

Prevalence of senile pruritus in Chinese population: a meta-analysis

目的系统评价中国老年性皮肤瘙痒症的患病率。方法计算机检索PubMed、EMbase、CENTRAL、CINAHL、CBM、CNKI、WanFang Data和VIP数据库,收集有关中国老年性皮肤瘙痒症患病率的横断面研究,检索时限均为建库至2019年5月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 12.0软件进行Meta分析。结果共纳入11个研究,包括13 398例患者。Meta分析结果显示:中国老年性皮肤瘙痒症的总患病率为31.0%[95%CI(18.0%,44.0%)]。亚组分析结果显示:男性患病率为34.9%[95%CI(18.6%,88.5%)];60、70、80、90岁组老年性皮肤瘙痒症的患病率分别为20.0%[95%CI(14.2%,25.7%)]、48.4%[95%CI(21.5%,75.3%)]、53%[95%CI(12.4%,93.5%)]、58.5%[95%CI(22.4%,94.6%)];社区、医院、干休所组老年性皮肤瘙痒症患病率分别为33.4%[95%CI(31.3%,35.6%)]、40.4%[95%CI(22%,58.7%)]、14.4%[95%CI(1.1%,27.7%)];南方、北方地区老年性皮肤瘙痒症患病率分别为26.7%[95%CI(18.7%,34.7%)]、36.8%[95%CI(21.8%,51.7%)]。结论我国老年性皮肤瘙痒症患病率较高,但不同年龄、地区、研究场所人群患病率存在差异。

Objectives To systematically review the prevalence of senile pruritus(SP) in Chinese population.Methods PubMed, EMbase, CENTRAL, CINAHL, CBM, CNKI, WanFang Data and VIP databases were electronically searched to collect cross-sectional studies on the prevalence of SP in Chinese population from inception to May 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies, then, metaanalysis was performed by Stata 12.0 software. Results A total of 11 studies involving 13 398 patients were included. The results of meta-analysis showed that, the overall prevalence of SP was 31.0%(95%CI 18.0% to 44.0%). Subgroup analysis showed that the prevalence rate of male was 34.9%(95%CI 18.6% to 88.5%). The prevalence rates of SP among 60, 70, 80 and 90 age groups were 20.0%(95%CI 14.2% to 25.7%), 48.4%(95%CI 21.5% to 75.3%), 53%(95%CI 12.4% to 93.5%), and58.5%(95%CI 22.4% to 94.6%), respectively. The prevalence rates of SP in community, hospital and cadre relaxation club were 33.4%(95%CI 31.3% to 35.6%), 40.4%(95%CI 22% to 58.7%), and 14.4%(95%CI 1.1% to 27.7%), respectively. The prevalence rates of SP in southern China and northern China were 26.7%(95%CI 18.7% to 34.7%) and 36.8%(95%CI21.8% to 51.7%), respectively. Conclusions The overall prevalence rate of SP in the Chinese population is high. The prevalence rates of SP among ages, regions and research sites are different.