中西医结合治疗对闭合性骨折患者临床疗效及炎症因子改善的影响

Effect of combine traditional Chinese and western medicine on early inflammatory factors and hemorheology in patients with closed fracture

目的分析针对闭合性骨折患者应用活血健骨汤的临床疗效以及对患者炎性因子和血流变的影响。方法选取2016年10月-2018年10月北京中医药大学附属护国寺中医医院收治的闭合性骨折患者80例,随机分为对照组和观察组各40例。对照组行常规手法复位联合夹板或石膏固定,而观察组在该基础上加用中药汤剂治疗。结果两组疗程前TNF-α、IL-1、IL-6测定结果差异无统计学意义(P>0.05);疗程结束后观察组的TNF-α、IL-1、IL-6测定结果均低于对照组(P<0.05);两组治疗前各血流变指标测定结果差异无统计学意义(P>0.05);治疗结束后观察组的血浆黏度、高切全血黏度、中切全血黏度以及低切全血黏度测定结果均低于对照组(P<0.05);治疗后观察组的疼痛、肿胀、功能障碍的症状积分均低于对照组(P<0.05);观察组的骨折愈合时间为(36.26±4.17)d,对照组为(47.62±5.96)d,对比差异有统计学意义(P<0.05)。结论针对闭合性骨折者口服活血健骨汤有助于改善其炎性因子和血流变指标,有助于促进患者骨折愈合。

Objective To analyze the clinical efficacy of Huoxue jiangu decoction in patients with closed fracture and the specific effects on inflammatory factors and hemorheology in patients.Methods The control group received conventional manual reduction combined with splint or cast immobilization,while the observation group was treated with self-made Huoxue jiangu decoction on the basis.Results The results of TNF-α,IL-1 and IL-6 were higher in the two groups(P>0.05).The results of TNF-α,IL-1 and IL-6 in the observation group were lower than those in the control group(P<0.05);The blood rheology indexes of the two groups before treatment were higher(P>0.05);the plasma viscosity,high cut whole blood viscosity,medium cut whole blood viscosity and low cut whole blood viscosity of the observation group after the treatment The results were lower than the control group(P<0.05).The symptom scores of pain,swelling and dysfunction in the observation group were lower than those in the control group(P<0.05).The fracture healing time of the observation group was(36.26±4.17)d,the control group was(47.62±5.96)d(P<0.05).Conclusion Oral Huoxuejiangu decoction for patients with closed fractures can improve the inflammatory factors and blood rheology indexes,and help to promote fracture healing.