急诊感染患者凝血障碍与脓毒症严重程度的关系

The Relationship between Coagulation Disorder and Sepsis Severity in Patients with Emergency Infection

目的:探讨急诊感染患者凝血障碍与脓毒症严重程度之间的关系。方法:随机选取我院2018年2~10月间收治的急诊感染患者90例作为研究对象,根据其脓毒症严重程度进行分组,其中A组为单纯感染患者(n=30),B组为脓毒症患者(n=30),C组为重度脓毒症患者(n=30),为所有患者实施常规凝血功能检测。结果:C组患者序贯器官衰竭(SOFA)评分高于A组、B组(P<0.05);C组患者病死率高于A组、B组(P<0.05);C组患者血小板计数、D-二聚体均高于A组、B组(P<0.05);三组患者的纤维蛋白原、活化部分凝血活酶时间、凝血酶时间、凝血酶原时间比较差异均无统计学意义(P>0.05)。结论:急诊感染患者凝血障碍与脓毒症严重程度之间存在密切关联性,在判断患者脓毒症严重程度时,应重视患者的凝血功能检测。

Objective:To investigate the relationship between coagulation disorder and sepsis severity in patients with emergency infection.Methods:90 patients with emergency infection were randomly selected in our hospital from February 2018 to October 2018,and were grouped according to the severity of sepsis.Among them,group A were pure infection patients(n=30),group B were sepsis patients(n=30),and group C were severe sepsis patients(n=30),and routine coagulation function test was carried out for all patients.Results:The score of sequential organ failure(SOFA)in group C was higher than that in group A and group B(P<0.05).The mortality rate in group C was higher than that in group A and group B(P<0.05).The decrease of platelet count and the increase of D-dimer in group C were higher than those in group A and group B(P<0.05).There were no significant differences in fibrinogen,activated partial thromboplastin time,thrombin time,and prothrombin time among the three groups of patients(P>0.05).Conclusion:There is a close relationship between coagulation disorder and sepsis severity in patients with emergency infection.In judging the severity of sepsis,attention should be paid to the detection of coagulation function in patients with sepsis.