养阴和血解毒方药在肛瘘术后创面愈合中的应用价值研究

Effect of Yangyin Hexue Jiedu Precription on Wound Healing in Anal Fistula Patients After Operation

【目的】观察养阴和血解毒方药对肛瘘术后创面愈合的治疗效果。【方法】将80例行肛瘘切开术的低位单纯性肛瘘(中医证型为阴虚内热型)患者随机分为观察组和对照组,每组各40例。2组患者均给予行肛瘘切开术治疗及术后常规处理,在此基础上,观察组给予养阴和血解毒方药口服治疗,对照组给予维生素C片口服治疗,疗程为3周。观察2组患者的创面愈合时间、创面坏死组织脱落时间、创面肉芽组织水肿和溃疡发生情况,并评估2组的综合疗效。【结果】(1)综合疗效方面,观察组的治愈率为90.0%,对照组为77.5%,观察组的疗效略优于对照组,但差异无统计学意义(P>0.05)。(2)观察组的创面平均愈合时间为(23.37±3.67)d,对照组为(28.52±4.35)d,观察组的创面平均愈合时间较对照组明显缩短(P<0.01)。(3)观察组的创面坏死组织脱落时间为(2.82±0.63)d,对照组为(4.25±0.92)d,观察组的创面坏死组织脱落时间明显短于对照组(P<0.01)。(4)观察组的创面肉芽组织水肿发生率和溃疡发生率分别为20.0%和2.5%,明显低于对照组的45.0%和22.5%(P<0.05或P<0.01)。【结论】养阴和血解毒方药能有效促进肛瘘术后创面愈合,缩短愈合时间,改善肉芽组织生长质量。

Objective To observe the therapeutic effect of Yangyin Hexue Jiedu Prescription on wound healing in anal fistula patients after operation.Methods Eighty low simple anal fistula patients differentiated as the syndrome of yin deficiency with internal heat were randomly assigned to observation group and control group,40 cases in each group.All of the patients in the two groups were given anal fistulotomy and then were treated with postoperative conventional management,and additionally,the observation group was given Yangyin Hexue Jiedu Prescription orally,and the control group was given vitamin C tablets orally for 3 weeks.The wound healing time,time for falling off of wound necrotic tissue,and incidence of wound granulation tissue edema and ulcer in the two groups were observed,and the comprehensive therapeutic efficacy of the two groups was also evaluated.Results(1)The cure rate in the observation group was 90.0%,and was mildly higher than the control group(77.5%),the difference being insignificant(P>0.05).(2)The average wound healing time in the observation group was(23.37±3.67)d,and that in the control group was(28.52±4.35)d,indicating that the healing time in the observation group was shorter than that in the control group(P<0.01).(3)Time for falling off of wound necrotic tissue in the observation group was(2.82±0.63)d,and that in the control group was(4.25±0.92)d,indicating that the time for falling off of wound necrotic tissue in the observation group was shorter than that in the control group(P<0.01).(4)The incidence of granulation tissue edema was 20.0%and the incidence of granulation tissue ulcer was 2.5%in the observation group,markedly lower than those in the control group(45.0%,22.5%respectively),and the differences were statistically significant(P<0.05 or P<0.01).Conclusion Yangyin Hexue Jiedu Prescription can effectively promote wound healing after anal fistula operation through shortening healing time and improving the quality of granulation tissue growth.