摘要
目的:观察中药化痰行气消瘀法治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的疗效及对血清白细胞介素-18(IL-18)和缺氧诱导因子-1α(HIF-1α)水平的影响。方法:将90例OSAHS患者按照随机数字表法分为2组,每组45例,两组均接受常规干预,对照组同时口服多索茶碱片,每次0.2g,每日2次,治疗组同时口服中药鼾证消组方,每日1剂,两组均连续治疗4周。比较两组治疗前后主要中医证候积分、多导睡眠检测(PSG)相关指标、血清IL-18、HIF-1α水平,并比较两组治疗总有效率。结果:治疗后治疗组主要中医证候睡时打鼾、鼾声停止呼吸暂停、白天嗜睡积分低于对照组(P<0.01);睡眠呼吸暂停低通气指数(AHI)、氧减指数(ODI)、氧饱和度<90%时间(T90)、微觉醒指数(MAI)低于对照组(P<0.01),平均氧饱和度(SaO_2)高于对照组(P<0.01);血清IL-18、HIF-1α水平低于对照组(P<0.01),治疗总有效率高于对照组(P<0.05),差异均有统计学意义。结论:化痰行气消瘀法可有效降低血清IL-18、HIF-1α水平,改善PSG指标和中医证候积分,治疗OSAHS效果显著,有临床推广应用价值。
Objective:To explore the therapeutic effect of applying Huatan Xingqi Xiaoyu Therapy in the treatment of ob-structive sleep apnea-hypopnea syndrome(OSAHS),and its influence on serum levels of interleukin-18(IL-18)and hypoxia inducible factor-1alpha(HIF-1alpha).Methods:Ninety patients with OSAHS were divided into two groups according to the digital random table method,with 45in each group.Both groups received routine intervention.The controlled group took Doxofyl-line Tablets orally,0.2g each time,twice a day.The treatment group also took the traditional Chinese medicine Hanzheng Xiao-zu Prescription orally,one dose a day.Both groups were treated continuously for 4weeks.The main TCM syndrome scores,PSG related indicators,serum levels of IL-18and HIF-1alpha were compared between the two groups before and after treatment,and the total effective rate of the two groups was compared.Results:After treatment,the scores of snoring,snoring apnea and day-time sleepiness of the treatment group were lower than those of the controlled group(P<0.01).The sleep apnea hypopnea index(AHI),oxygen reduction index(ODI),oxygen saturation<90%time(T90),micro-awakening index(MAI)were lower than those of the controlled group(P<0.01),and the average oxygen saturation(SaO2)was higher than that of the controlled group(P<0.01).The level of HIF-1alpha was lower than that of the controlled group(P<0.01),and the total effective rate was higher than that of the controlled group(P<0.05).The differences were statistically significant.Conclusion:Huatan Xingqi Xi-aoyu Therapy can effectively reduce the levels of IL-18and HIF-1a in serum,improve the PSG index and TCM syndrome inte-gral,so it has significant effect on OSAHS.It has clinical application value.
作者
芦慧
梁振
杨晓玲
LU Hui;LIANG Zhen;YANG Xiaoling(Department of Otolaryngology-Head and Neck Surgery,Tan-gshan Municipal Union Hospital(Tangshan Hebei 063000,China))
出处
《四川中医》
2020年第4期91-94,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
唐山市科技局科学计划项目(编号:13130276b)。