高血压患者血小板/淋巴细胞比值与颈动脉粥样硬化的相关性分析

Correlation Between Platelet/Lymphocyte Ratio and Carotid Atherosclerosis in Patients with Hypertension

目的探究原发性高血压(PH)患者的血小板/淋巴细胞比值(PLR)与颈动脉粥样硬化(CAS)的相关性。方法回顾性分析2018年1月~12月我院收治的PH患者274例,记录患者的性别、年龄、入院时的收缩压(SBP)和舒张压(DBP)、血小板计数(PLT)、淋巴细胞绝对值(L)、血小板/淋巴细胞比值(PLR)及双侧颈部血管彩超等资料。根据是否合并CAS分为CAS组和无CAS组,比较两组一般资料、SBP、DBP、PLT、L及PLR水平;Spearman相关性分析PH合并CAS的影响因素,多因素Logistic回归分析PH合并CAS的独立危险因素,ROC曲线评估PLR对PH合并CAS的预测价值。结果①无CAS组患者142例,CAS组患者132例,两组性别、DBP、PLT及L比较,差异无统计学意义(P>0.05);但CAS组年龄、SBP、PLR均高于无CAS组,差异有统计学意义(P<0.05)。②Spearman相关性分析显示,年龄、SBP、PLR与CAS呈正相关(r=0.411、0.410、0.563,P均<0.05),淋巴细胞绝对值与CAS呈负相关(r=-0.126,P<0.05)。③多因素Logistic回归分析显示,PLR是PH发生CAS的独立危险因素(OR=1.132,95%CI:1.091~1.175,P=0.000)。④ROC曲线分析显示,PLR预测PH患者出现CAS的曲线下面积(AUC)为0.825,95%CI:0.767~0.883。PLR的最佳截点为128.03,当PLR>128.03时,PLR预测PH患者出现CAS的敏感性和特异性分别为74.20%和92.30%。结论PLR与PH合并CAS具有一定的相关性,是PH合并CAS的独立预测危险因素,PLR值越大,CAS的发生风险越高。

Objective To investigate the correlation between platelet/lymphocyte ratio(PLR)and carotid atherosclerosis(CAS)in patients with essential hypertension(PH).Methods A retrospective analysis of 274 PH patients admitted in our hospital from January to December 2018.The gender,age,systolic blood pressure(SBP)and diastolic blood pressure(DBP),platelet count(PLT),Lymphocyte absolute value(L),platelet/lymphocyte ratio(PLR)and bilateral neck vascular color Doppler ultrasound and other data.According to whether the combined CAS is divided into the CAS group and the non-CAS group,the general data,SBP,DBP,PLT,L,and PLR levels of the two groups are compared;the Spearman correlation analysis analyzes the influencing factors of PH combined CAS,and the multivariate Logistic regression analysis analyzes the PH combined CAS.Independent risk factors,ROC curve evaluated the predictive value of PLR for PH combined CAS.Results①There were 142 patients in the non-CAS group and 132 patients in the CAS-group.There was no significant difference in gender,DBP,PLT,and L between the two groups(P>0.05).However,the age,SBP,and PLR of the CAS group were higher than those non-CAS group,the differences were statistically significant(P<0.05).②Spearman correlation analysis showed that age,SBP,and PLR were positively correlated with CAS(r=0.411,0.410,0.563,P<0.05),and absolute values of lymphocytes were negatively correlated with CAS(r=-0.126,P=0.037).③Multivariate Logistic regression analysis showed that PLR was an independent risk factor for CAS in PH(OR=1.132,95%CI:1.091~1.175,P=0.000).④ROC curve analysis showed that the area under the curve(AUC)predicted by PLR for CAS in patients with PH was 0.825,95%CI:0.767 to 0.883.The optimal cut-off point of PLR is 128.03.When PLR>128.03,the sensitivity and specificity of PLR to predict CAS in PH patients are 74.20%and 92.30%,respectively.Conclusions There is a certain correlation between PLR and PH combined CAS,which is an independent predictive risk factor for PH combined CAS.The larger the PLR value,the higher the risk of CAS.