血清BNP、TnⅠ及Hcy水平与急性肺栓塞患者病情严重程度及预后的关系

The Correlation Between of Serum BNP,TnⅠand Hcy Levels in the Severity and Prognosis of Patients with Acute Pulmonary Embolism

目的探讨急性肺栓塞患者血清B型利钠肽(BNP)、同型半胱氨酸(Hcy)和肌钙蛋白Ⅰ(TnⅠ)水平对其病情严重程度和预后的影响。方法选取2017年1月~2019年4月我院收治的102例急性肺栓塞患者作为观察组,根据不同病情程度分为低危、中危和高危患者,并随访6个月后根据不同预后将其分为存活和死亡患者;另选取同期我院体检的40名健康体检者作为对照组,比较观察组与对照组、不同病情程度及预后患者血清BNP、Hcy和TnⅠ水平。结果观察组BNP、Hcy和TnⅠ水平均高于对照组,差异有统计学意义(P<0.05);高危患者BNP、Hcy和TnⅠ水平高于中危患者和低危患者,中危患者BNP、Hcy和TnⅠ水平高于低危患者,差异有统计学意义(P<0.05);死亡患者BNP、Hcy和TnⅠ水平均高于存活患者,差异有统计学意义(P<0.05)。结论急性肺栓塞患者的血清BNP、Hcy和TnⅠ水平随着病情严重程度的增加而升高,可作为病情程度和预后的评估指标。

Objective To investigate the effects of serum B-type natriuretic peptide(BNP),homocysteine(Hcy)and troponinⅠ(TnⅠ)levels on the severity and prognosis of patients with acute pulmonary embolism.Methods A total of 102 patients with acute pulmonary embolism admitted in our hospital from January 2017 to April 2019 were selected as the observation group.They were divided into low-risk group(51 cases),intermediate-risk group(31 cases)and high-risk group(20 cases).After 6 months of follow-up,they were divided into survival group and death group according to different prognosis.Another 40 healthy people who were examined in our hospital during the same period were selected as the control group.The serum BNP,Hcy and TnⅠlevels were compared between the observation group and the control group,different disease groups and prognosis groups.Results The levels of BNP,Hcy,and TnⅠin the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The levels of BNP,Hcy,and TnⅠin the high-risk group were higher than those in the middle-risk group and the low-risk group.The levels of BNP,Hcy,and TnⅠin the middle-risk group were higher than those in the low-risk group,the differences were statistically significant(P<0.05).The BNP,Hcy,and TnⅠlevel was higher than that in the survival group,the difference was statistically significant(P<0.05).Conclusion The levels of serum BNP,Hcy and TnⅠin patients with acute pulmonary embolism increase with the severity of the disease,and can be used as indicators of disease severity and prognosis.