摘要
骨髓增生异常综合征是一种具有高度异质性的源于骨髓造血干细胞的克隆性疾病,免疫失衡和骨髓微环境异常在其发病机制中具有重要地位。骨髓间充质干细胞是骨髓微环境中重要的细胞成分,具有支持和调节造血干细胞的增殖和分化以及免疫调节的作用。骨髓间充质干细胞异常在骨髓增生异常综合征发病中表现为造血支持缺陷和免疫抑制,本文现就此机制进行综述。
Myelodysplastic syndrome is a highly heterogeneous clonal disease derived from bone marrow hematopoietic stem cells.Immunological imbalance and abnormal bone marrow microenvironment play an important role in its pathogenesis.Bone marrow mesenchymal stem cells are important cellular components in the bone marrow microenvironment,and have the role of supporting and regulating the proliferation and differentiation of hematopoietic stem cells and immune regulation.The abnormality of bone marrow mesenchymal stem cells in the pathogenesis of myelodysplastic syndrome manifests as defects in hematopoietic support and immunosuppression.This article reviews the mechanism.
作者
楼芸
周永明
朱文伟
LOU Yun;ZHOU Yong-ming;ZHU Wen-wei(Department of Hematology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
出处
《医学信息》
2020年第6期24-26,39,共4页
Journal of Medical Information
基金
国家自然科学基金面上项目(编号:81273734、81673939)
上海中医药大学高峰高原团队项目(编号:30304114341)
周永明上海市名老中医学术经验研究工作室项目(编号:SHGZS-2017019)
上海市“十三五”临床重点专科建设项目(编号:shslczdzk05201)。
关键词
骨髓增生异常综合征
间充质干细胞
骨髓微环境
造血支持缺陷
免疫抑制
Myelodysplastic syndrome
Mesenchymal stem cells
Bone marrow microenvironment
Hematopoietic support defects
Immunosuppression
