新生儿败血症诊断中的生物标志物研究现状

Research Status of Biomarkers in the Diagnosis of Neonatal Sepsis

新生儿败血症是引起新生儿死亡的一个重要疾病,早期诊断对于该病的预后至关重要,寻找具有高敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV)的理想生物标志物,以便尽早诊断和排除新生儿败血症,并指导合理使用抗生素,是目前临床研究热点和难点。尽管有许多生物标记物已被证实在早期诊断新生儿败血症起作用,但迄今为止,没有一个生物标记物能够满足理想生物标记物的所有标准。本文通过对近年来研究比较热门的生物标记物(降钙素原、c反应蛋白、脂多糖结合蛋白、白介素-6等)的研究现状及临床应用进行归纳总结,以期为临床诊断败血症提供一定帮助。

Neonatal sepsis is an important disease that causes neonatal death,and early diagnosis is essential for the prognosis of the disease.Finding ideal biomarkers with high sensitivity,specificity,positive predictive value(PPV)and negative predictive value(NPV),in order to diagnose and rule out neonatal sepsis as early as possible,and guide the rational use of antibiotics,is the current hot and difficult point of clinical research.Although many biomarkers have been shown to play a role in early diagnosis of neonatal sepsis,to date,no single biomarker has met all the criteria of an ideal biomarker.This article summarizes the research status and clinical application of the most popular biomarkers(procalcitonin,C-reactive protein,lipopolysaccharide binding protein,interleukin-6,etc.)in recent years,in order to provide some help for clinical diagnosis of sepsis.