PLR与乳腺癌预后的关系

The Relationship Between PLR and Breast Cancer Prognosis

乳腺癌是女性最常见的恶性肿瘤之一。生活压力的增加、精神高度紧张,快餐式饮食习惯及不规律的生活作息方式等因素导致女性乳腺癌发病率逐年升高,其患病率跃居中国女性恶性肿瘤的首位,并且发病呈年轻化趋势。尽管目前以手术为主的综合诊疗已取得了较大进步,但癌症相关死亡仍是导致患者死亡的主要原因。由于血液学参数具有取材简便、创伤性小、可重复取材等优点,近年来在乳腺癌预后的相关研究中逐渐增多,且越来越多的研究发现血小板与淋巴细胞的比值(PLR)与乳腺癌的预后密切相关。本文就血小板、淋巴细胞在肿瘤发生发展中的作用、PLR在乳腺癌新辅助治疗中的相关研究以及PLR与乳腺癌预后的关系作一综述。

Breast cancer is one of the most common malignancies in women.Increasing life pressure,high mental stress,fast-food eating habits and irregular lifestyles and other factors have led to an increase in the incidence of breast cancer in women year by year,and its prevalence ranks first among Chinese women's malignant tumors,and the incidence is younger.Although great progress has been made in surgery-based comprehensive diagnosis and treatment,cancer-related deaths are still the leading cause of death.Because hematological parameters have the advantages of simple and convenient material extraction,less trauma,and easy to repeatedly obtain materials,in recent years,there have been increasing researches on hematological parameters and breast cancer prognosis.More and more studies have proved the platelet to lymphocyte ratio(PLR).It is closely related to the prognosis of breast cancer.The higher the PLR value,the worse the prognosis of the patient.This article reviews the role of platelets and lymphocytes in tumorigenesis and development,related research on PLR in neoadjuvant treatment of breast cancer,and related research on PLR and breast cancer prognosis.