氯吡格雷联合阿司匹林治疗急性心肌梗死的研究

A Study of Clopidogrel Combined with Aspirin in the Treatment of Acute Myocardial Infarction

急性心肌梗死(AMI)属于冠心病最严重类型,其指冠状动脉突发性闭塞,造成心肌缺血、损伤或坏死性疾病。该病病理基础多为冠状动脉粥样硬化、冠状动脉痉挛,易导致血栓形成,阻塞血管,具有较高病死率及致残率,现已成为临床研究重点。血小板聚集在该疾病发展中具有重要作用,而抗血栓及抗血小板治疗可有效预防血栓形成,降低AMI发生率。氯吡格雷与阿司匹林均属于抗血栓类药物,可有效阻滞血小板聚集,预防血栓形成,现被临床广泛应用于心脑血管疾病治疗中。本文就氯吡格雷和阿司匹林作用机制、治疗AMI的临床价值、不良反应作一综述,以期为临床用药提供参考。

Acute myocardial infarction(AMI)is the most severe type of coronary heart disease,which refers to sudden occlusion of coronary arteries,causing myocardial ischemia,injury or necrotic disease.The pathological basis of the disease is mostly coronary atherosclerosis and coronary spasm,which easily lead to thrombosis and block blood vessels.It has a high mortality and disability rate,and has become the focus of clinical research.Platelet aggregation plays an important role in the development of the disease,and antithrombotic and antiplatelet therapy can effectively prevent thrombosis and reduce the incidence of AMI.Both clopidogrel and aspirin are antithrombotic drugs that can effectively block platelet aggregation and prevent thrombosis.They are now widely used in the treatment of cardiovascular and cerebrovascular diseases.This article reviews the mechanism of action of clopidogrel and aspirin,its clinical value in treating AMI,and adverse reactions in order to provide a reference for clinical use.