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参麦注射液联合阿德福韦酯治疗乙肝肝硬化失代偿期的疗效 被引量:2

Effect of Shenmai Injection Combined with Adefovir Dipivoxil on Decompensation of Hepatitis B Cirrhosis
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摘要 目的观察临床乙肝肝硬化失代偿期应用参麦注射液联合阿德福韦酯治疗效果。方法选取2018年4月~2019年4月在天津市中医药研究院附属医院治疗的50例乙肝肝硬化失代偿期患者为研究对象,采用随机数字表法分为对照组和观察组,各25例。对照组给予保肝对症治疗联合阿德福韦酯治疗,观察组在对照组基础上联合参麦注射液治疗,比较两组临床治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)]、凝血指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)]、HBV-DNA转阴率以及并发症发生情况。结果治疗后两组ALT、ALT、TBIL均低于治疗前,且观察组低于对照组(P<0.05);治疗后两组PT、APTT、TT均低于治疗前,且观察组低于对照组(P<0.05);治疗后观察组HBV-DNA转阴率为88.00%,高于对照组的72.00%(P<0.05)。结论参麦注射液联合阿德福韦酯治疗乙肝肝硬化失代偿期,可有效改善凝血功能,保护肝功能,延迟肝损害,抑制HBV-DNA的复制。 Objective To observe the therapeutic effect of Shenmai injection combined with adefovir dipivoxil in the decompensated stage of clinical hepatitis B cirrhosis.Methods A total of 50 patients with decompensated hepatitis B liver cirrhosis who were treated in the affiliated hospital of Tianjin Academy of Traditional Chinese Medicine from April 2018 to April 2019 were selected as the research subjects.They were divided into control group and observation group by random number table method,each 25 example.The control group received symptomatic liver protection combined with adefovir dipivoxil.The observation group was combined with Shenmai injection on the basis of the control group.The liver function indicators[alanine aminotransferase(ALT),propyl]were compared between the two groups before and after clinical treatment.Amino acid aminotransferase(ALT),total bilirubin(TBIL),coagulation indicators[prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT)],HBV-DNA negative rate and complications.Results After treatment,the ALT,ALT,and TBIL in the two groups were lower than before treatment,and the observation group was lower than the control group(P<0.05);after treatment,the PT,APTT,and TT were lower in both groups than before treatment,and the observation group was lower than the control group(P<0.05).After treatment,the HBV-DNA negative rate of the observation group was 88.00%,which was higher than 72.00%of the control group(P<0.05).Conclusion Shenmai injection combined with adefovir dipivoxil in the treatment of decompensation of hepatitis B cirrhosis can effectively improve blood coagulation function,protect liver function,delay liver damage,and inhibit HBV-DNA replication.
作者 吕奕 王毓麟 LYU Yi;WANG Yu-lin(Department of Medical Affairs,Tianjin Xiqing Hospital,Tianjin 300380,China;Department of Gastroenterology,the Affiliated Hospital of Tianjin Academy of Chinese Medicine,Tianjin 300120,China)
出处 《医学信息》 2020年第6期162-163,共2页 Journal of Medical Information
关键词 参麦注射液 阿德福韦酯 乙肝肝硬化 失代偿期 Shenmai injection Adefovir dipivoxil Hepatitis B liver cirrhosis Decompensation period
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