早期妊娠患者血清β-HCG、P、E2水平检测在稽留流产诊断中的价值

Value of Serumβ-HCG,P,E2 Levels in Early Pregnancy Patients in the Diagnosis of Missed Abortion

目的探讨早期妊娠血清中人绒毛膜促性腺激素(β-HCG)、孕酮(P)、雌二醇(E2)水平检测在稽留流产诊断中的价值。方法选择2017年8月~2019年8月以早期妊娠就诊于安徽医科大学附属安庆市立医院妇产科门诊的孕妇156例,根据妊娠结局分为胚胎停育组(n=71)和正常妊娠组(n=85),各组根据停经天数分为≤42 d、43~49 d、>49 d,应用化学发光分析法检测两组β-HCG、P、E2水平,比较两组不同停经天数β-HCG、P、E2水平。结果正常妊娠组不同停经天数血清β-HCG、P、E2水平均高于胚胎停育组,差异有统计学意义(P<0.05)。结论胚胎停育患者不同停经天数β-HCG、E2、P水平均较正常妊娠患者低,β-HCG、P、E2水平检测有助于诊断稽留流产。

Objective To investigate the value of detection of human chorionic gonadotropin(β-HCG),progesterone(P)and estradiol(E2)in serum of early pregnancy in the diagnosis of missed abortion.Methods From August 2017 to August 2019,156 pregnant women who were diagnosed with early pregnancy in the Obstetrics and Gynecology clinic of Anqing Municipal Hospital of Anhui Medical University were divided into embryo termination group(n=71)and normal pregnancy group according to pregnancy outcome(n=85).Each group was divided into≤42 days,43-49 days,and>49 days according to the number of menopause days.The levels ofβ-HCG,P,and E2 were detected by chemiluminescence analysis,and the levels ofβ-HCG,P,and E2 were compared between the two menopausal days.Results The levels of serumβ-HCG,P,and E2 in the different periods of menopause in the normal pregnancy group were higher than those in the embryonic abortion group,the difference was statistically significant(P<0.05).Conclusion The levels ofβ-HCG,E2,and P are lower in patients with embryonic abortion than those in normal pregnancy,detection ofβ-HCG,P,E2 levels is helpful in diagnosing missed abortion.