心肌酶谱水平检测诊断心力衰竭的意义

Significance of Myocardial Enzyme Level Detection in Diagnosis of Heart Failure

目的研究心肌酶谱水平检测在诊断心力衰竭患者中的价值。方法选取2018年1月~2019年1月在我院诊治的120例心力衰竭患者设为观察组,选取同期体检健康者80例设为对照组,检测心肌酶谱乳酸脱氢酶(LDH)、肌酸激酶(CK)、α羟基丁酸脱氢酶(α-HBDH)、肌酸激酶同工酶(CK-MB)水平,比较两组心肌酶谱水平、观察组不同心功能分级患者心肌酶谱水平及治疗前后心肌酶谱水平。结果观察组治疗前LDH、CK、α-HBDH、CK-MB均高于对照组,差异有统计学意义(P<0.05);治疗后观察组LDH、CK、α-HBDH、CK-MB均低于治疗前,且高于对照组,差异有统计学意义(P<0.05);心功能Ⅱ、Ⅲ、Ⅳ级患者LDH、CK、α-HBDH、CK-MB水平均高于心功能Ⅰ级患者,差异有统计学意义(P<0.05),心功能分级越高,患者的心肌酶谱指标水平越高。结论心力衰竭患者心肌酶谱水平高于健康人群,且心功能越差,心肌酶谱水平越高,临床检测心肌酶谱水平可为心力衰竭患者的诊断、治疗以及心衰情况提供参考依据。

Objective To study the value of detection of myocardial enzymes in the diagnosis of patients with heart failure.Methods 120 patients with heart failure diagnosed and treated in our hospital from January 2018 to January 2019 were selected as the observation group,and 80 healthy patients who were checked during the same period were selected as the control group.The myocardial enzyme lactate dehydrogenase(LDH),muscle Acid kinase(CK),α-hydroxybutyric acid dehydrogenase(α-HBDH),creatine kinase isoenzyme(CK-MB)levels,compare the levels of myocardial enzymes in the two groups,and compare the myocardial enzymes in patients with different cardiac function grades levels and myocardial enzymes before and after treatment.Results The LDH,CK,α-HBDH,and CK-MB in the observation group were higher than those in the control group before treatment,the differences were statistically significant(P<0.05).After treatment,the LDH,CK,α-HBDH,and CK-MB in the observation group were lower than before treatment and higher than the control group,the difference was statistically significant(P<0.05);The levels of LDH,CK,α-HBDH,and CK-MB in patients with cardiac functionⅡ,Ⅲ,andⅣwere higher than those in patients with cardiac functionⅠ,the difference was statistically significant(P<0.05),and the higher the cardiac function classification,the higher the level of myocardial enzymes.Conclusion The level of myocardial enzymes in patients with heart failure is higher than that in healthy people,and the worse the heart function,the higher the level of myocardial enzymes.The clinical detection of myocardial enzymes can provide reference for the diagnosis,treatment and heart failure of patients with heart failure.