二十五味珊瑚丸治疗脑梗死30例临床观察

Clinical Observation on the Treatment of 30 Cases of Cerebral Infarction with Ershiwuwei Shanhu Pill

目的:观察二十五味珊瑚丸治疗脑梗死的临床效果。方法:选取60例急性脑梗死患者,随机分为对照组与治疗组各30例,对照组采用抗血小板聚集、强化调脂、护脑、扩管、降压等对症支持治疗,治疗组对照组在基础上加用二十五味珊瑚丸口服;治疗21d后进行血生化检测及NIHSS功能评分,评价临床疗效及其对肝肾功能血脂、心肌酶谱、同型半胱氨酸的影响。结果:与对照组相比,治疗组治疗前NIHSS评分差异无统计学意义(P>0.05),治疗组治疗前后NIHSS评分显著降低,差异具有统计学意义(P<0.05);对照组总胆固醇(TCHO)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)水平差异具有统计学意义(P<0.05);治疗组治疗前后TCHO、LDL-C、甘油三酯(TG)、尿酸水平差异具有统计学意义(P<0.05);与对照组相比,治疗组治疗后TG水平降低,存在统计学差异具有统计学意义(P<0.05),治疗组治疗前后ALT、AST、BUN、CREA、CK、UA存在统计学差异(P<0.05),与对照组相比,治疗后ALT、AST、CK、CKMB、BUN水平有所升高,但差异具有统计学意义(P>0.05)。结论:二十五味珊瑚丸治疗脑梗死疗效确切,但存在一定的心肝肾功能影响,其机制可能与其调节血脂有关。

Objective To observe the clinical effect of Ershiwuwei shanhu Pill in the treatment of cerebral infarction.Methods 60 patients with acute cerebral infarction diagnosed were selected and divided into control group and treatment group according to random number table.In control group,symptomatic supportive treatment including anti-platelet aggregation,intensive lipid-lowering,brain protection,catheter expansion and antihypertensive were used,treatment group using control group treatment and Ershiwuwei shanhu Pill oral.After 21 days of treatment,blood biochemistry was taken and NIHSS function score was performed to evaluate the clinical efficacy and its effects on liver and kidney function,blood lipid,Myocardial Zymogram and homocysteine.Results Compared with the control group,there was no statistical difference in NIHSS score before and after treatment in the treatment group(P>0.05),and NIHSS score before and after treatment in the treatment group was significantly lower,there was statistical difference(P<0.05);the level of total cholesterol(TCHO),low-density lipoprotein(LDL-C),high-density lipoprotein(HDL-C)in the control group was statistically different before and after treatment(P<0.05);the level of total cholesterol and low-density lipoprotein egg in the treatment group before and after treatment Compared with the control group,the TG level of the treatment group was lower and there was statistical difference(P<0.05).The alt,AST,bun,crea,CK and UA levels of the treatment group before and after treatment were statistically different.Compared with the control group,the alt,AST,CK,CKMB and BUN levels of the treatment group were increased,but there was no statistical difference(P>0.05).Conclusion The therapeutic effect of 25 Wei coral Pill on cerebral infarction is definite,but it has some influence on the function of heart,liver and kidney,and its mechanism may be related to the regulation of blood lipid.