肠道菌群调控2型糖尿病发生发展的研究进展

Research progresses of intestinal flora regulating the occurrence and the development of type 2 diabetes mellitus

作为一个高度适应性且组成复杂的特殊"器官",肠道菌群在2型糖尿病的发生发展和治疗中发挥着重要作用。肠道菌群种类繁杂,数量庞大,可以发酵不易消化的碳水化合物以及蛋白质,产生各种代谢产物,代谢产物通过不同的机制调节糖脂代谢,从而影响机体生理功能。本文对肠道菌群及其代谢物与2型糖尿病的发生发展及发病机制的相关研究进行简要阐述,以期为2型糖尿病的预防、诊断、治疗及预后提供新的策略和研究靶点。

As a highly adaptable,complicated and special organism,intestinal flora plays an important role indevelopment and treatment of type 2 diabetes mellitus. With large quantity and rich diversity,intestinal flora is able to ferment indigestible carbohydrates and proteins and produce metabolites which could affect physiological functions of organism,especially modulate glycolipid metabolism via different mechanisms. In this paper,we briefly elucidates related researches on intestinal flora and the occurrence,development and pathogenesis of type 2 diabetes mellitus,in order to provide new strategies and research targets for the prevention,diagnosis,treatment and prognosis of type 2 diabetes.