麝香保心丸对2型糖尿病患者尿微量白蛋白/肌酐比值的影响

Effect of Shexiangbaoxin pill on urine microalbumin/creatinine ratio in type 2 diabetes patients

目的:观察并探讨麝香保心丸对2型糖尿病患者尿微量白蛋白的作用。方法:收集2016年7月至2017年1月复旦大学附属华山医院东院收治的2型糖尿病患者68例,随机分成对照组和中药组各34例。对照组予以基础治疗,中药组在对照组基础上服用麝香保心丸,治疗6个月后检测并比较两组患者身体质量指数(BMI)、腰臀比(WHR)、血压、空腹血糖(FBG)、血脂、肾功能、高敏C反应蛋白(hs-CRP)和尿微量白蛋白/肌酐比(UACR)等指标。结果:治疗后,中药组血胆固醇(TC)、低密度脂蛋白(LDL-C)水平明显低于对照组(P<0.05),hs-CRP和UACR较对照组也明显降低(P<0.05)。结论:麝香保心丸能改善2型糖尿病患者微量白蛋白尿,其机制可能与降低hs-CRP、改善内皮细胞功能有关。

Objective:To observe and explore the effect of Shexiangbaoxin pill on urine microalbumin in patients with type 2 diabetes(T2 D).Methods:Sixty-eight T2 D patients,who were admitted into East Courtyard of Huashan Hospital affiliated to Fudan University from July 2016 to January 2017,were collected and randomly divided into a control group and a Chinese medicine group with 34 cases in each group.The control group received the basic treatment,while the Chinese medicine group took Shexiangbaoxin pill on the basis of the control group.After 6 months of treatment,the indexes such as body mass index(BMI),waist-to-hip ratio(WHR),blood pressure(BP),fasting blood glucose(FBG),blood lipids,renal function,high-sensitivity C-reactive protein(hsCRP)and urine microalbumin/creatinine ratio(UACR)and other indicators were compared between the two groups.Results:After treatment,the levels of blood total cholesterol(TC)and low density lipoprotein-cholesterol(LDL-C)in the Chinese medicine group were significantly lower than those in the control group(P<0.05),and hs-CRP and UACR in the Chinese medicine group were also significantly lower than those in the control group(P<0.05).Conclusion:Shexiangbaoxin pill can improve microalbuminuria in patients with type 2 diabetes,and the mechanism may be related to reducing hs-CRP and improving endothelial cell function.