老年人群高尿酸血症与血脂水平的相关性研究

Study of the correlation between hyperuricemia and serum lipids in the elderly population

目的:通过分析老年人群血尿酸与血脂水平,探究老年人高尿酸血症与血脂代谢紊乱之间的关系。方法:研究纳入社区9385名60岁以上老年人,其中男性4265例,平均年龄(69.52±7.07)岁;女性5120例,平均年龄(70.00±7.41)岁。通过问卷调查、体格检查与实验室检查获得老年人的健康信息。结果:在9385名老年人中的高尿酸血症检出率为22.87%。高尿酸血症组老年人的体重指数、高血压患病率、总胆固醇(TC)、三酰甘油(TG)水平均显著高于尿酸正常组。高密度脂蛋白胆固醇(HDL-c)明显低于尿酸正常组。多因素logistic回归分析发现TC和TG是老年人高尿酸血症的风险因素,HDL-c是老年人高尿酸血症的保护因素。结论:老年人群血尿酸水平与血脂水平密切相关,在老年人高尿酸血症的早期筛查与防治中应当同时也重视对于血脂水平的检测。

Objective:To explore the relationship between hyperuricemia and dyslipidemia in the elderly by analyzing the levels of serum uric acid and serum lipids in the elderly population.Methods:A total of 9385 adults over 60 years old were included in the study,and among them there were 4265 males with the average age of(69.52±7.07)years old and 5120 females with the average age of(70.00±7.41)years old.The health information of the elderly was obtained by the questionnaire,physical examination and laboratory examination.Results:The detection rate of hyperuricemia in 9385 elderly people was 22.87%.The body mass index,prevalence of hypertension,total cholesterol(TC)and triglyceride(TG)levels of the elderly in the hyperuricemia group were significantly higher than those in the normal uric acid group.High density lipoprotein cholesterol(HDL-C)in the hyperuricemia group was significantly lower than that in normal uric acid group.Multivariate logistic regression analysis found that TC and TG were risk factors for hyperuricemia in the elderly,and HDL-C was a protective factor for hyperuricemia in the elderly.Conclusion:The blood uric acid level is closely related to the blood lipid level in the elderly,and in the early screening and prevention of hyperuricemia in the elderly attention should also be paid to the detection of blood lipid level.