摘要
经过实验验证引入水有利于芳香醛、丙二腈和邻苯二甲酰肼三组分的反应进行,催化量的有机碱三乙胺(Et 3 N)或无机碱磷酸氢二钾(K 2 HPO 4[DK1]·3H 2 O)可以在常规条件下促进该反应。本文以39%~97%的产率合成一系列1 H-吡唑[1,2-b]酞嗪-5,10-二酮衍生物。两种催化剂均溶于水,因此,反应结束后催化剂的分离与产物提纯简便易行。此方法具有反应条件温和、绿色环保、操作简单、后处理方便等特点。
Catalytic amount of organic base triethylamine(Et 3 N)or inorganic base dipotassium hydrogen phosphate(K 2 HPO 4[DK1]·3H 2 O)is proved to effectively promote the three components reaction of aromatic aldehyde,malononitrile and phthalhydrazide under conventional heating conditions.As expected,introduction of water is favorable to the reaction.A series of 1 H-pyrazole[1,2-b]pyridazine-5,10-diones derivatives was synthesized in the yield of 39%~97%.Both catalysts are soluble in water,and introduction of water also facilitate the separation of the catalyst after reaction.This approach also has advantages of mild reaction conditions,green environmental protection,simple operation and convenient post-treatment.
作者
陈晨
阮鸿力
吕乐
宋芷熙
吕成伟
安悦
CHEN Chen;RUAN Hongli;LV Le;SONG Zhixi;LV Chengwei;AN Yue(College of Chemistry and Chemical Engineering,Liaoning Normal University,Dalian,Liaoning 116029,China)
出处
《应用化学》
CAS
CSCD
北大核心
2020年第5期502-511,共10页
Chinese Journal of Applied Chemistry
基金
辽宁省科技厅(2019-MS-215,2019-ZD-0470)项目资助。
关键词
三乙胺
磷酸氢二钾
碱催化
多组分反应
酞嗪衍生物
trimethylamine
dipotassium hydrogen phosphate trihydrate
base catalytic
multi-component reactions
phthalazines derivatives