肺炎支原体IgM、IgG和血清CRP、PCT水平在小儿支原体肺炎诊疗中的检测价值

Detection value of mycoplasma pneumoniae IgM,IgG,Serum CRP and PCT levels in diagnosis and treatment of mycoplasma pneumoniae pneumonia in children

目的:探讨肺炎支原体(MP)IgM、IgG和血清C反应蛋白(CRP)、降钙素原(PCT)水平在小儿支原体肺炎(MPP)诊疗中的检测价值。方法:根据胸部CT或X线影像学表现,将100例MPP患儿分为支气管肺炎组(n=67)和大叶性肺炎组(n=33)。另选取同期来院体检的40名健康同龄儿童,记为健康组。检测MPP患儿和健康组儿童MP-IgM、MP-IgG阳性率和血清CRP、PCT表达水平,并观察MPP患儿急性期和恢复期血清CRP、PCT水平变化。结果:MPP组MP-IgM、MP-IgG阳性率均明显高于健康组(χ^2=17.400、17.197,P<0.01);支气管肺炎组MP-IgM阳性率和大叶性肺炎组比较,差异无统计学意义(P>0.05),MP-IgG阳性率低于大叶性肺炎组,差异有统计学意义(χ^2=6.505,P<0.01);MPP患儿入院时血清CRP、PCT水平分别高于恢复期及健康组,差异有统计学意义(P<0.01);支气管肺炎组和大叶肺炎组血清CRP、PCT水平比较,差异无统计学意义(P>0.05)。结论:MP-IgM、MP-IgG和血清CRP、PCT水平检测对早期诊断小儿MPP、评估感染程度和病情转归具有较高价值。

Objective:To explore the value of Mycoplasma pneumoniae(MP)IgM,IgG,serum C-reactive protein(CRP),procalcitonin(PCT)levels in the diagnosis and treatment of mycoplasma pneumoniae pneumonia(MPP)in children.Methods:According to the chest CT or X-ray findings,100 MPP children were divided into bronchopneumonia group(n=67)and lobar pneumonia group(n=33).Another 40 healthy children of the same age who came to the hospital for physical examination at the same time were selected as the health group.The positive rates of MP-IgM,MP-IgG and the expression levels of CRP and PCT in serum of MPP children and healthy children were detected,and the changes of serum CRP and PCT levels in acute and convalescent MPP children were observed.Results:The positive rates of MP-IgM and MP-IgG in MPP group were significantly higher than those in healthy group(χ^2=17.400,17.197,P<0.01).The positive rates of MP-IgM in bronchopneumonia group and lobar pneumonia group were not significantly different(P>0.05),while the positive rates of MP-IgG in bronchopneumonia group were lower than those in lobar pneumonia group(χ^2=6.505,P<0.01).The levels of serum CRP and PCT in hospital were higher than those in convalescent and healthy groups(P<0.01),but there was no significant difference between bronchopneumonia group and lobar pneumonia group(P>0.05).Conclusion:Detection of MP-IgM,MP-IgG,serum CRP and PCT levels is of great value in early diagnosis of MPP in children,evaluation of infection degree and prognosis.