PINK1、Parkin与泛素协同调控线粒体自噬的研究进展

Research Progress in PINK1,Parkin and Ubiquitin Concerted Regulation of Mitophagy

线粒体自噬是指真核细胞通过自噬将损伤的线粒体进行选择性降解的过程,在冠心病、肥厚性心肌病及心力衰竭等疾病的发生、发展过程中起重要的作用。通过线粒体自噬,细胞能降解损伤的线粒体细胞器及有害代谢物质以维持线粒体及细胞的稳态。PTEN诱导的假定激酶1(PTEN-induced putative kinase 1,PINK1)、Parkin以及泛素在线粒体自噬中起到重要作用。线粒体膜电位受损后,PINK1识别损伤的线粒体并在其表面聚集,与Parkin以及泛素协同作用促进线粒体的泛素化以启动线粒体自噬。另外,自噬受体在线粒体自噬过程中也起到重要作用。

Mitophagy refers to the process that eukaryotic cells selectively degrade damaged mitochondria by autophagy.It plays important roles in the onset and development of diseases such as coronary heart disease,hypertrophic cardiomyopathy and heart failure.Cells can degrade damaged mitochondrial and harmful metabolites to maintain mitochondria and cell homeostasis by mitophagy.PTEN-induced putative kinase 1(PINK1),Parkin and ubiquitin play important roles in mitophagy.When mitochondrial membrane potential is impaired,PINK1 recognize damaged mitochondria and aggregate on its surface,synergize with Parkin and ubiquitin to promote mitochondrial ubiquitination to initiate mitophagy.Besides,autophagy receptors also play important roles in mitophagy.