PKC在神经病理性疼痛机制中的研究进展

Research Progress of PKC in Mechanism of Neuropathic Pain

蛋白激酶C(PKC)是一种磷脂和钙依赖性蛋白激酶,参与了细胞内信号的转导,调节细胞的增殖和死亡,增加基因的转录和翻译,调节离子通道和受体等,与疼痛、癌症、糖尿病以及心力衰竭等疾病的发生相关。PKC对神经病理性疼痛的调节作用是疼痛机制研究的热点。神经病理性疼痛是一种慢性疼痛,极大降低了患者的生活质量,其发生基础是中枢敏化和外周敏化。PKC通过调节离子通道和受体引起外周敏化和中枢敏化,参与神经病理性疼痛,但其具体机制尚不清楚。目前,离子通道(电压门控钠通道、电压门控钙离子通道、超极化激活的环核苷酸门控阳离子通道、瞬时受体电位通道)、兴奋性/抑制性神经递质及其受体、P2X受体家族和sigma-1受体等在神经病理性疼痛发生机制中研究较多,有望为神经病理性疼痛的治疗提供新思路。

Protein kinase C(PKC)is a type of phospholipids and calcium-dependent protein kinase,which is involved in the transduction of intracellular signals,thereby regulating cell proliferation and death,increasing gene transcription and translation,regulating ion channels and receptors and so on,thus is associated with the occurrence of diseases such as pain,cancer,diabetes and heart failure.The regulation of PKC on neuropathic pain is a hot topic in the research of pain mechanisms.Neuropathic pain is a chronic pain that significantly reduces the patients′quality of life.The basis of its occurrence is central and peripheral sensitization.PKC causes peripheral sensitization and central sensitization by regulating ion channels and receptors,which is involved in neuropathic pain,however,the specific mechanism is still not clear.At present,ion channels(voltage-gated sodium channels,voltage-gated calcium channels,hyperpolarization-activated cyclic nucleotide-modulated channels,transient receptor potential channels),excitatory/inhibitory neurotransmitters and receptors,P2X receptor family,and sigma-1 receptors have been studied in the pathogenesis of neuropathic pain,which are expected to provide new ideas for the treatment of neuropathic pain.