摘要
微RNA(miRNA)是一类小的非编码RNA,可以通过抑制翻译调控30%基因的信使RNA翻译过程。miRNA的异常表达与许多疾病相关,包括妇科疾病、恶性肿瘤、炎症性疾病和心血管疾病。在多种生殖系统疾病中也可观察到miRNA的异常表达,包括子痫前期、复发性流产、宫颈癌、子宫内膜癌、卵巢癌、子宫平滑肌瘤、子宫内膜异位症和盆腔器官脱垂。目前,miRNA与妇科疾病之间的相互作用关系得到了更新,不仅涵盖了miRNA失调在各种妇科疾病起源中的影响,还揭示了miRNA在妇科恶性肿瘤、子宫内膜异位症等妇科疾病中发挥的潜在诊断和治疗作用。
MicroRNAs(miRNAs)are a class of small non-coding RNAs that can regulate the messenger RNA translation process of 30%genes by inhibiting translation.Abnormal miRNA expression is associated with many diseases,including gynecologic diseases,malignant tumors,inflammatory diseases and cardiovascular diseases.Abnormal miRNA expression has also been observed in a variety of reproductive system diseases,including preeclampsia,recurrent abortion,cervical cancer,endometrial cancer,ovarian cancer,uterine leiomyoma,endometriosis,and pelvic organ prolapse.Currently,the understanding of the interaction between miRNA and gynecologic diseases has been updated,which not only covers the influence of miRNA disorders on the origin of various gynecologic diseases,but also reveals the potential diagnostic and therapeutic role of miRNA in gynecologic malignancies,endometriosis and other gynecologic diseases.
作者
逄子瑶
彭越
赵郑
陈勇华
侯建青
PANG Ziyao;PENG Yue;ZHAO Zheng;CHEN Yonghua;HOU Jianqing(Department of Gynaecology,the Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai 264000,China;School of Medicine,Yantai Campus of Binzhou Medical College,Yantai 264000,China)
出处
《医学综述》
2020年第10期1956-1961,1967,共7页
Medical Recapitulate
关键词
微RNA
宫颈癌
子宫内膜癌
卵巢癌
盆腔器官脱垂
MicroRNA
Cervical carcinoma
Endometrial carcinoma
Ovarian carcinoma
Pelvic organ prolapse
