滋水疏木法对卵巢早衰患者卵巢血流灌注及窦卵泡计数的影响

The Effect of Nourishing Liver and Kidney Method on Ovarian Blood Perfusion and Antral Follicle Count in Patients with Premature Ovarian Failure

目的利用三维能量多普勒超声观察滋水疏木法对卵巢早衰患者卵巢血流灌注及窦卵泡计数的影响。方法将80例肾虚肝郁型卵巢早衰患者随机分为对照组和观察组,每组各40例。对照组采用克龄蒙治疗,观察组给予滋水疏木法中药。比较2组患者治疗前后的卵巢体积(OV)、窦卵泡计数(AFC)和卵巢的血管化指数(VI)、血流指数(FI)和血管化血流指数(VFI)。结果治疗后,2组患者卵巢体积略有增大,但差异无统计学意义(P>0.05);2组患者窦卵泡数目均明显增多(P<0.05),且观察组优于对照组(P<0.05);对照组卵巢的血管化指数(VI)、血流指数(FI)和血管化血流指数(VFI)均恢复明显(P<0.05),且观察组血管化指数(VI)恢复明显优于对照组(P<0.05);血流指数(FI)和血管化血流指数(VFI)优于对照组,但无统计学意义(P>0.05)。结论滋水疏木法能有效恢复卵巢早衰患者的卵巢储备功能,显著提高受损卵巢中窦卵泡数量,明显改善受损卵巢的血流灌注。

Objective Three-dimensional power Doppler ultrasound was used to observe the clinical efficacy of the nourishing liver and kidney method on ovarian blood perfusion and antral follicle count in patients with premature ovarian failure. Methods Eighty patients with POF with kidney deficiency and liver stagnation syndrome were randomly divided into the observation group and the control group, with 40 cases in each group. The ones in the control group were treated with Climen, while the ones in the observation group were treated with the traditional Chinese medicine nourishing liver and kidney method. The Antral follicle count(AFC), the ovarian volume(OV), the vascularisation index(VI), the flow index(FI), and the vascularisation flow index(VFI) before and after the treatment in the two groups were compared. Results After the treatment, the OV increased slightly in both groups, and the difference was not statistically significant(P>0.05). The AFC in both groups increased significantly(P<0.05), and the observation group was superior to the control group(P<0.05). The VI, FI,VFI of the control group all recovered significantly(P<0.05) after the treatment, and the VI in the observation group was significantly better than that of the control group(P<0.05) after the treatment, and the FI and VFI were superior to the control group after the treatment, and the difference was not statistically significant(P>0.05). Conclusion The nourishing liver and kidney method can effectively restore the ovarian reserve function of patients with premature ovarian failure,significantly increase the AFC in the damaged ovary, and significantly improve the blood perfusion of the damaged ovary.