摘要
子宫自然杀伤(uterine natural killer, uNK)细胞是哺乳动物妊娠早期胎盘蜕膜中数量最多的免疫细胞。妊娠期间,uNK细胞对子宫免疫耐受环境建立,胎盘以及胎儿的发育等均具有重要调控作用。目前,有关妊娠中uNK细胞独特生物活性调控机制研究非常缺乏。本文综合相关研究,介绍了妊娠过程中uNK细胞在母-胎免疫耐受建立、胎盘和胎儿发育过程中重要调控作用,并总结激素、糖代谢以及DNA甲基化等对其他组织NK细胞调控机制研究,为探索uNK细胞调控分子机制提供新的研究方向和思路。
Uterine natural killer cells are the most abundant immune cells in deciduate placenta in the early pregnancy of mammals.During pregnancy,uNK cells play the important regulation role in the establishment of uterine immunotolerance environment,the development of placenta and fetus.However,studies on the regulation mechanisms of unique biological activity of uNK cells in pregnancy are limited.According to the related researches,the presentation of the important regulation role of uNK cells in the establishment of maternal-fetal immunotolerance environment and the development of placenta and fetus were well given in this paper,and the regulatory mechanism of hormones,glucose metabolism and DNA methylation on NK cells in other tissues were well summarized in order to provide new research directions and ideas for exploring the molecular regulation mechanism of uNK cells.
作者
杨晓伟
赵永聚
YANG Xiaowei;ZHAO Yongju(College of Animal Science,Southwest University,Chongqing 402460,China;College of Animal Science and Technology,Southwest University,Chongqing 400715,China)
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2020年第5期899-906,共8页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金面上项目(31772564)
重庆市自然科学基金(基础研究与前沿探索)面上项目(cstc2019jcyj-msxmX0140)。
关键词
子宫自然杀伤细胞
妊娠
调控作用
uterine natural killer cells
pregnancy
regulation role
