基于专利分析看肝脏组织工程领域的竞争态势

The competitive situation of liver tissue engineering based on patent analysis

背景:中国是肝病高发国家,肝脏组织工程为治疗带来了新的希望,但目前此技术仍处于探索阶段。目的:对肝脏组织工程领域的专利进行分析,揭示全球技术竞争态势,为中国肝脏组织工程的发展与创新提供借鉴和参考。方法:对近20年肝脏组织工程领域的专利数量与发展趋势、技术发源地、目标市场、申请机构、发明人和技术分布等进行分析,全文检索关键词包括组织工程(tissueengineering)、组织修复或组织再生(tissue regenerate/repair)和肝(hepatic/liver)等。检索截止时间为2018年12月28日。结果与结论:①全球肝脏组织工程领域发展速度较快,近10年复合增长率8.64%,其中发明专利占84.93%。②中国是全球肝脏组织工程最主要的技术发源地。但三方专利数量远不及美国和日本。③中国和美国是肝脏组织工程领域的最受关注的两大目标市场,但申请人多集中于本国,国际授权数量较少。④在专利权人和发明人排名中,中国分别有8家机构和14位申请人跻身全球前20。⑤结果证实,从专利分析结果来看,中国肝脏组织工程技术发展迅猛,跻身国际前列,但缺乏核心技术,各研发主体还应不断提升创新能力,挖掘高价值技术,从而提高国际竞争力。

BACKGROUND:China is a country with high incidence of liver disease.Liver tissue engineering,which is still in the stage of exploration,has brought a new hope for treatment.OBJECTIVE:To provide advices and references for the development and innovation of liver tissue engineering based on patent analysis.METHODS:The number and development tendency,as well as the technology birthplace,target market,applicants,inventors and technical fields of patents in the field of liver tissue engineering in nearly 20 years were analyzed in this study.The keywords for full-text search included tissue engineering,tissue regenerate/repair,and hepatic/liver.The retrieval deadline was December 28,2018.RESULTS AND CONCLUSION:There is a rapid development in the field of the global liver tissue engineering.The compound growth rate in the past 10 years is 8.64%,of which invention patents account for 84.93%.China is the main technology birthplace;however,the number of tripartite patents of China is far less than that of the United States and Japan.China and the United States are the two most high-profile target markets in the field of liver tissue engineering,but the applicants are mostly from native instead of international.Meanwhile,there are 8 Chinese application institutions and 14 Chinese inventors ranking among the top 20 in the world in this field.In conclusion,liver tissue engineering has developed rapidly in China,but the lack of core technology is still an important issue.Therefore,we must improve our innovation capabilities and explore core technologies continuously to enhance our international competitiveness.