Kartogenin在软骨再生修复中的应用及价值

Recent advances and applications of Kartogenin in cartilage regeneration and repair

背景:骨关节炎等软骨损伤性疾病所导致的软骨缺损,难以自我再生,如何促进软骨再生恢复创面的光滑是近年研究的热点。目的:综述Kartogenin的一般概念、作用机制和效果以及目前所应用的临床模型,为损伤软骨的再生和修复提供新的思路。方法:检索2010年1月至2020年1月万方、知网、Pub Med数据库收录的关于kartogenin与组织工程结合在软骨再生修复领域及研究进展的相关文献,包括综述、基础研究及临床研究。中文检索词为"Kartogenin,软骨再生修复,软骨保护,组织工程",英文检索词为"Kartogenin,cartilage regeneration,chondrogenesis,chondroprotection"。通过阅读文题和摘要进行初步筛选,排除与文章主题相关度低的文献,根据纳入标准和排除标准,最终纳入55篇文献进行结果分析。结果与结论:①Kartogenin作为一种新发现的小分子,具有更好的稳定性、免疫原性低和易于获得性;②此外,Kartogenin与生长因子在软骨再生中具有协同作用,在软骨形成和软骨保护方面具有极大的潜力;③通过体外实验或动物实验,已经证明Kartogenin在软骨生成、骨关节炎治疗、腱骨损伤修复、创伤愈合等方面具有积极的促进作用,并且有助于保护终板软骨及椎间盘的退变及肩袖损伤的愈合;④随着对Kartogenin更多的基础研究及临床试验,软骨再生修复会在不久的将来取得突破。

BACKGROUND:Cartilage defects due to cartilage lesions such as osteoarthritis are difficult toself-regenerate.How to promote cartilage regeneration and restore smooth wound surface is a hot topic in recent years.OBJECTIVE:To review the general concept,mechanism and effect of Kartogenin as well as the current clinical models,providing new ideas for the regeneration and repair of damaged cartilage.METHODS:Wan Fang,CNKI,and Pub Med were retrieved for studies on Kartogenin combined with tissue engineering in the field of cartilage regeneration and repair published from January 2010 to January 2020.The keywords were"Kartogenin,cartilage regeneration,chondrogenesis,chondroprotection"in English and"Kartogenin,cartilage regeneration and repair,cartilage protection,tissue engineering"in Chinese.After initial screening by reading titles and abstracts,irrelevant literature was excluded and finally 55 articles were included for result analysis according to the inclusion criteria and exclusion criteria.RESULTS AND CONCLUSION:As a newly discovered small molecule,Kartogenin has better stability,lower immunogenicity and easy availability.In addition,Kartogenin plays a synergistic role with growth factors in cartilage regeneration and has great potential in cartilage formation and cartilage protection.Through in vitro experiments or animal experiments,it has been proved that Kartogenin plays a positive role in promoting cartilage generation,osteoarthritis treatment,repair of tendon and bone injury,and wound healing,and helps to protect the degeneration of cartilage and healing of rotator cuff injury.With more basic research and clinical trials on Kartogenin,a breakthrough in cartilage regeneration and repair will be made in the near future.