摘要
目的探讨不同产地、不同品种的山楂样品对胰脂肪酶活性的抑制作用。方法以对硝基苯基丁酸酯作为底物,在405 nm波长测定山楂饮片样品的水提物对胰脂肪酶体外活性。结果各批次山楂样品对胰脂肪酶活性具有一定的抑制作用。结论山楂可用于预防和治疗肥胖症;胰脂肪酶活性可作为山楂饮片等级划分的生物效应指标。
Objective To investigate the inhibition of pancreatic lipase activity by hawthorn products from different producing areas and different varieties.Methods Using p-nitrophenylbutyrate as a substrate,the in vitro activity of water extracts of hawthorn pieces on pancreatic lipase was measured at 405 nm.Results Hawthorn samples from various batches had a certain inhibitory effect on pancreatic lipase activity.Conclusion Hawthorn can be used to prevent and treat obesity;pancreatic lipase activity can be used as an indicator of biological effects of hawthorn slices.
作者
李强
徐天任
吕畅
戴衍朋
LI Qiang;XU Tianren;LYU Chang;DAI Yanpeng(Dongying Food and Drug Inspection Center,Dongying 257091,China;Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong University,Jinan 250012,China;Shandong Academy of Chinese Medicine,Jinan 250014,China)
出处
《药学研究》
CAS
2020年第5期261-265,共5页
Journal of Pharmaceutical Research
基金
国家重点研发计划(No.SQ2018YFC170003)
山东省重点研发计划(No.2019GSF108150)
国家中药标准化项目(No.ZYBZH-Y-SD-33)
国家中医药行业科研专项(No.201507002-2)
山东省中医药科技发展计划(No.2013-132)。
关键词
胰脂肪酶
山楂
肥胖
Pancreatic lipase
Hawthorn
Obesity
