妊娠中晚期维生素A和E水平与子痫前期相关性分析

Analysis of Vitamin A and E Levels in the Second and Third Trimester of Pregnancy and Their Correlation with Preeclampsia

【目的】检测孕妇妊娠中晚期血清维生素A、E水平,探讨维生素A、E水平与子痫前期发病的相关性。【方法】收集2016年8月至2019年9月潮州市人民医院产科门诊产检并分娩孕妇资料,子痫前期142例,随机选取正常妊娠患者1200例作为对照组,收集中、晚孕期维生素A、E、孕前BMI、年龄、sd-LDL,分析其与子痫前期的关系。【结果】子痫前期组与正常对照组妊娠中、晚期维生素A、E水平差异无统计学意义(P>0.05),Logistic回归分析表明妊娠期维生素A、E水平与子痫前期无相关性,孕前BMI、年龄、sd-LDL与子痫前期存在关联性。【结论】孕妇血清维生素A、E水平与子痫前期的发病无明显相关性,孕前BMI、年龄、sd-LDL为子痫前期发生的独立危险因素。

【Objective】To test the levels of vitamin A and E in serum of pregnant women in the second and third trimester of pregnancy and study the relevance between the levels of vitamin A and E in serum and the incidence of preeclampsia.【Methods】Totally 142 cases of preeclampsia were collected from pregnant women who got prenatal care and had delivery at the Obstetrics Department,Chaozhou People′s Hospital between August,2016 and September,2019,and 1200 cases of normal pregnancy were randomly selected.Data including levels of vitamin A and E in the second and third trimester of pregnancy,pregestational BMI,age,sd-LDL were collected for the analysis of their relevance with preeclampsia.【Results】The differences in the levels of vitamin A and E in the second and third trimester of pregnancy between the preeclampsia group and the control group of normal pregnancy were not statistically significant(P>0.05).According to Logistic regression analysis,there were no correlations between the levels of vitamin A and E in the second and third trimester of pregnancy and preeclampsia while there was an association between preeclampsia and pregestational BMI,age,and sd-LDL.【Conclusion】The levels of vitamin A and E in serum of pregnant women have no significant correlation with the incidence of preeclampsia,while pregestational BMI,age,and sd-LDL are independent risk factors for preeclampsia.