中国汉族人群脂联素+276位点基因多态性与2型糖尿病相关性的meta分析

Correlation of adiponectin gene+276 in exon 2 polymorphisms and type 2 diabetes mellitus in Chinese Han population:a meta-analysis

目的通过meta分析评估中国汉族人群脂联素基因(adiponectin,ADIPOQ)+276G/T(rs1501299)位点单核苷酸多态性与2型糖尿病(T2DM)的相关性。方法检索自2000年1月1日至2018年12月31日PubMed、Ovid、CBM、Springer、CNKI和WanFang Data中关于中国汉族人群脂联素基因rs1501299(+276G/T)与2型糖尿病相关性的病例-对照研究,并辅以文献追溯。采用Review Manager 5.3软件进行meta分析。结果共纳入13项研究,其中T2DM患者3 384例,健康对照者3 187例。meta分析结果显示,在隐性遗传模式下,两组差异有统计学意义[OR=1.29,95%CI(1.13, 1.49),P<0.05]。该位点基因多态性meta分析结果发表偏倚较小,研究纳入的样本量大、精度较高,所有研究组都具有较好代表性。结论中国汉族人群脂联素基因+276G/T位点基因多态性与2型糖尿病可能具有相关性。

Objective To evaluate the association between adiponectin ADIPOQ+276G/T(rs1501299)single nucleotide polymorphisms and type 2 diabetes mellitus(T2DM)in the Chinese Han population via a meta-analysis.Methods A search,supplemented by literature traceability,was conducted for the case-control studies about the association between adiponectin gene rs1501299(+276G/T)and T2DM in Chinese Han population from PubMed,Ovid,CBM,Springer,CNKI and WanFang Data from Jan.1,2000 to Nov.25,2018.The meta-analysis was performed using Review Manager 5.3.Results A total of 13 studies were included with 3 384 T2DM patients and 3187 healthy people as controls.The meta-analysis showed that the difference between the two groups was statistically significant[OR=1.29,95%CI(1.13,1.49),P<0.05].Gene polymorphism at this locus was less biased with large samples and high accuracy,all the study groups having good representativeness.Conclusion Polymorphism of adiponectin+276G/T locus in Chinese Han population may be correlated to T2DM.