纤维蛋白原与白蛋白比值与冠心病合并2型糖尿病患者冠状动脉支架内再狭窄的相关性

Correlation of ratio of fibrinogen to albumin and in-stent restenosis in patients with coronary heart disease and type 2 diabetes mellitus

目的分析纤维蛋白原与白蛋白比值(FAR)与冠心病合并2型糖尿病(T2DM)患者冠状动脉支架内再狭窄的相关性。方法回顾性分析因冠心病合并T2DM接受经皮冠状动脉介入治疗(PCI)183例患者的临床资料。患者均于术后1年行冠状动脉造影;其中,发生冠状动脉支架内再狭窄42例(A组),未发生冠状动脉支架内再狭窄141例(B组)。比较两组患者临床资料、生化指标及冠状动脉造影结果。采用logistic回归分析冠状动脉支架内再狭窄发生的影响因素。结果A组吸烟比例、纤维蛋白原水平和FAR高于B组,支架直径小于B组(P<0.05)。多因素logistic回归分析显示,FAR升高、吸烟和支架直径小是冠状动脉支架内再狭窄发生的危险因素(P<0.05)。结论FAR升高对PCI后冠状动脉支架内再狭窄具有一定的预测价值,是支架内再狭窄发生的危险因素。

Objective To analyze the correlation between the ratio of fibrinogen to albumin(FAR)and coronary artery in-stent restenosis(ISR)in the patients with coronary heart disease and type 2 diabetes mellitus(T2 DM).Methods The clinical data of 183 patients with coronary artery disease and T2 DM underwent percutaneous coronary intervention(PCI)were retrospectively analyzed.The patients were followed up by coronary angiography 1 year after surgery,which showed coronary artery ISR in 42 cases(group A)and no coronary artery ISR in 141 cases(group B).The clinical data,biochemical parameters and coronary angiography results were compared between two groups.Multivariate logistic regression was used to analyze the influencing factors of coronary artery ISR.Results The percentage of the patients with smoking,fibrinogen level and FAR were higher and stent diameter was smaller in group A than those in group B(P<0.05).Multivariate logistic regression analysis showed that increased FAR,smoking and short stent diameter were the risk factors for coronary artery ISR(P<0.05).Conclusion An increase of FAR is a risk factor for coronary artery ISR and has a certain value in predicting coronary artery ISR after PCI.