中老年2型糖尿病患者肌少症相关因素研究

Relevant factors of sarcopenia in middle-aged and elderly patients with type 2 diabetes mellitus study of sarcopenia-related factors of in middle-aged and elderly patients with type 2 diabetes mellitus

目的通过研究中老年2型糖尿病(type 2 diabetes mellitus,T2DM)患者肌少症(Sarcopenia)发生的危险因素,为预防和治疗肌少症提供思路。方法收集2018年5~11月于郑州大学第一附属医院内分泌科住院的289例中老年T2DM患者作为研究对象,以同期该院57名正常体检人群作为对照组,比较两组患者一般资料、血生化、HbA1c、肌力等指标的差异及两组肌少症的检出率。对两定量资料进行Pearson相关分析及Logistic回归分析,分析肌少症发生的危险因素。结果T2DM组中肌少症的检出率(22.83%)大于正常对照组(12.28%)(P<0.05)。T2DM组中,全身骨骼肌肌肉含量与体重、体质量指数(body mass index,BMI)、全髋部骨密度、腹部脂肪面积、25(OH)D3含量呈正相关,与空腹血糖、糖尿病病程呈负相关。低BMI、低全髋部骨密度、低25(OH)D3、长糖尿病病程是肌少症发生的危险因素。结论2型糖尿病患者是肌少症发生的危险人群,针对T2DM患者发生肌少症的相关危险因素采取干预措施,可减少跌倒、骨折、致残、致死事件的发生。

Objective To evaluate the risk factors of sarcopenia in middle-aged and elderly patients with type 2 diabetes mellitus(T2DM)for the prevention and treatment of sarcopenia.Methods Data of 289 middle-aged and elderly patients with T2DM in the Department of Endocrinology,the First Affiliated Hospital of Zhengzhou University from May to November 2018 were collected.Fifty-seven healthy people during the same period were selected as the control group.The difference of general data,biochemistry,HbA1c,muscle strength,and the detection rate of sarcopenia between the two groups were compared.Pearson correlation analysis and Logistic regression analysis were used to analyze the risk factors of sarcopenia.Results The detection rate of sarcopenia in the T2DM group(22.83%)was higher than that in the normal control group(12.28%,P<0.05).In T2DM group,skeletal muscle content was positively correlated with body weight,BMI,bone mineral density of the total hip,abdominal fat area,and 25(OH)D3 content,but was negatively correlated with fasting blood glucose and diabetes duration.Low BMI,low 25(OH)D3,low total hip bone mineral density,and long course of diabetes were risk factors for sarcopenia.Conclusion T2DM patients are risk population of sarcopenia.Intervention against the risk factors of sarcopenia may reduce the occurrence of falls,fractures,disabilities,and fatal events in T2DM patients.