围绝经期妇女骨折风险与内脏脂肪量的相关性研究

Correlation between fracture risk and visceral fat mass in perimenopausal women

目的应用骨折风险评估工具(FRAX)计算围绝经期妇女(40~50岁)骨质疏松性骨折风险,探讨围绝经期妇女骨折风险与内脏脂肪量的内在联系。方法分析2017年3月至2018年3月334例围绝经期妇女的问卷资料(年龄、体重、烟酒史、既往骨折史、激素应用情况等),通过双能X线扫描获得定量指标骨密度值及内脏脂肪量,采用FRAX软件计算骨折风险,并与内脏脂肪量进行相关性分析。结果围绝经期妇女随年龄增加,骨密度值逐渐减少,骨折风险逐渐增高;内脏脂肪量与骨密度呈负相关(r=-0.35,P<0.05);内脏脂肪量与骨折风险呈正相关(r=0.58,P<0.05)。结论FRAX能精准反映围绝经期妇女骨折风险,有助临床提前干预;内脏脂肪是导致骨质疏松性骨折的致病因子之一。

Objective Using the Fracture Risk Assessment Tool(FRAX),to calculate the risk of osteoporotic fracture and to explore the intrinsic relationship between fracture risk and visceral fat mass in 40-50-years-old perimenopausal women.Methods Questionnaire data of 334 perimenopausal women,including age,weight,smoking and alcohol history,previous fracture history,hormone application,etc.,from March 2017 to March 2018,were analyzed.Quantitative indexes of bone mineral density(BMD)and visceral fat were obtained with dual energy X-ray scanning.Fracture risk was calculated using FRAX software.The correlation between BMD and visceral fat was analyzed.Results BMD decreased and fracture risk increased gradually with age in perimenopausal women.Visceral fat was negatively correlated with BMD(r=-0.35,P<0.05),but was positively correlated with fracture risk(r=0.58,P<0.05).Conclusion FRAX accurately reflects the risk of fracture in perimenopausal women and it is helpful for early clinical intervention.Visceral fat is one of the pathogenic factors leading to osteoporotic fracture.