ASPH在肝脏恶性肿瘤发生发展中作用和机制研究进展

RESEARCH ADVANCES IN THE ROLE AND MECHANISM OF ASPARTYL-(ASPARAGINYL)-β-HYDROXYLASE IN THE DEVELOPMENT AND PROGRESSION OF LIVER MALIGNANCIES

天冬氨酰-(天冬酰胺酰)β-羟化酶(ASPH)是α-酮戊二酸依赖性双加氧酶,催化天冬氨酰和天冬酰胺基残基的羟化。ASPH在肝细胞癌和肝内胆管癌中均有表达,对二者的发生和发展有作用。本文主要对ASPH的结构和功能及其作用机制的研究进展进行综述。

Aspartyl-(asparaginyl)-β-hydroxylase(ASPH)is aα-ketoglutarate-dependent dioxygenase and catalyzes the hydroxylation of aspartyl and asparaginyl residues.ASPH is expressed in both hepatocellular carcinoma and intrahepatic cholangiocarcinoma and has an effect on the development and progression of these two diseases.This article reviews the research advances in the structure,function,and mechanism of ASPH.