寨卡病毒抑制剂研究新进展

Progress on the discovery and development of anti-zika virus agents

寨卡病毒(ZIKV),作为一种由蚊虫传播的黄病毒,感染后期会导致严重的神经系统并发症,如格林-巴利综合征。寨卡病毒感染对孕妇及胎儿的影响尤为显著,会造成新生儿小头畸形。2015年在巴西流行之后,寨卡病毒由于其毒力增加的趋势和传播迅速等特点引起了国际社会的广泛关注。然而目前仍没有可用于治疗寨卡病毒感染的抗病毒药物上市。本综述总结了近几年抗寨卡病毒感染药物研究的新进展,并对该领域的研究趋势进行了展望。

Zika virus(ZIKV)is a kind of mosquito-borne flavivirus.ZIKV infection initially shows mild symptoms on patients,but will lead to severe neurological complications(such as Guillain-Barrésyndrome)in the end.Meanwhile,pregnant women are sensitive to ZIKV,since the viruses may cause microcephaly.In 2015,after the epidemic in Brazil,ZIKV draws the public attention around the world because of its increased virulence and rapid dissemination.However,there is no approved specific anti-ZIKV drugs at present.This review summarizes progress on anti-zika virus drug research and provides prospects in this field.