摘要
登革热是由埃及伊蚊和白纹伊蚊传播的一种虫媒病毒的疾病。登革病毒感染能够引发登革热、登革出血热和登革休克综合征等多种症状。迄今为止尚无治疗登革病毒感染的特异性药物上市。本文结合抗登革病毒研究的最新进展,从蛋白酶抑制剂、病毒多聚酶抑制剂、病毒侵入抑制剂、病毒复制相关宿主因子抑制剂以及衣壳蛋白抑制剂等几个方面综述了抗登革病毒药物研究新进展。
Dengue fever is one of the most important vector-borne human diseases caused by mosquito vector Aedes aegypti and Aedes albopictus.Dengue virus can cause dengue fever,dengue hemorrhagic fever and dengue shock syndrome.There are no approved drugs for the treatment of dengue disease so far.In this paper,combined with the latest progress in the research of anti-dengue virus,the new progress in the research of anti-dengue virus drugs was reviewed from the aspects of protease inhibitors,virus polymerase inhibitors,entry inhibitors,virus replication-related host factor inhibitors,capsid protein inhibitors and nucleic acid inhibitors.
作者
侯凌欣
鞠翰
展鹏
刘新泳
HOU Ling-xin;JU Han;ZHAN Peng;LIU Xin-yong(Department of Medicinal Chemistry,Key Laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China)
出处
《药学学报》
CAS
CSCD
北大核心
2020年第4期669-678,共10页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81420108027,81573347)
山东省重点研发计划(2017CXGC1401,2019JZZY021011)。
关键词
登革热
登革热病毒
登革出血热
药物发现
dengue fever
dengue virus
dengue hemorrhagic fever
drug discovery