摘要
病毒感染一直威胁着人类的生命健康。广谱抗病毒药物可以通过靶向对病毒复制至关重要的宿主蛋白,作用于多种病毒或同一病毒的多种基因型,来发挥广谱抗病毒作用、并减少耐药性的发生。本文精选近几年最具代表性的研究实例,从药物化学的角度总结了具有特定优势结构和靶向病毒生命周期中特定靶标的广谱抗病毒药物的最新进展。
Viral infections have always threatened human health.Broad-spectrum antiviral agents(BSAs)can either target host proteins that are essential for viral replication,or act on multiple viruses or multiple genotypes of the same virus.More importantly,BSAs could reduce the possibility of drug resistance.From the perspective of medicinal chemistry,this review summarizes recent advances in the research of broad-spectrum antiviral drugs with privileged structures or targeting specific targets in the viral life cycle.
作者
黄天广
孙林
展鹏
刘新泳
HUANG Tian-guang;SUN Lin;ZHAN Peng;LIU Xin-yong(Department of Medicinal Chemistry,Key Laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China)
出处
《药学学报》
CAS
CSCD
北大核心
2020年第4期679-693,共15页
Acta Pharmaceutica Sinica
基金
国家自然科学基金面上项目(81773574)
山东省重点研发计划(2017CXGC1401,2019JZZY021011)。
关键词
广谱
抗病毒药物
药物靶标
优势结构
broad-spectrum
antiviral agent
drug target
privileged structure