成人注意缺陷多动障碍在内外源冲突时的表现:眼动的证据

Adult attention deficit hyperactivity disorder in internal and external conflicts: Evidence from Saccade task

在注意定向与维持上,注意缺陷多动障碍(ADHD)个体更容易受到外部刺激的干扰而导致目标任务加工进程受阻,表现出了注意定向反应的缺陷,但导致任务失败的原因是由于对突然出现的外部无关刺激的过度兴奋还是对内源性目标刺激的持续维持能力减弱,尚不清楚。研究采用反向眼跳范式、记忆导向眼跳范式和视觉导向眼跳范式,来探索成人ADHD内外源注意定向反应的情况,以及当二者发生冲突时,成人ADHD失败的可能机制。结果发现,在反向眼跳任务上,成人注意缺陷多动障碍组错误率更高,并且差异性显著。但在记忆导向眼跳任务中,成人注意缺陷多动障碍组与正常组的差异不显著。在视觉导向眼跳任务中,成人注意缺陷多动障碍组的正确眼跳潜伏期比正常组要短,且二者之间的差异显著。这说明,在内外源刺激反应的冲突导致的情境中,成人注意缺陷多动障碍的反应明显落后于正常个体,这种缺陷并非由于其维持内源性注意产生定向反应落后所导致的,而是与其外源注意定向反应过强有关。

Attention-deficit/hyperactivity disorder(ADHD) is a childhood onset disorder with the cardinal features of inattention, impulsivity, and hyperactivity. And the core symptoms of ADHD in childhood will gradually change into more serious neurological disorders in adulthood. Thus, it is necessary to study the pathological and physiological mechanisms of adult ADHD patients. Compared with normal people, patients with ADHD have stronger exogenous stimulation drive ability and weaker endogenous control ability. Therefore, the reason why ADHD in adults is susceptible to external interference is whether the level of response generated exogenous stimulation is too strong or the level of response generated by endogenous driving is too weak. Twenty-six adult ADHD patients were screened by adult ADHD self-reporting scale(ASRS) as ADHD group, and 25 normal adult participants were selected as control group. Three experimental paradigms of saccade(reverse saccade, memory-oriented saccade and visual-oriented saccade) were used to investigate the ability of endogenous and exogenous saccade conversion and the ability of endogenous and exogenous saccade production and maintenance. The results showed that the response level of adult ADHD patients to endogenous stimulation was lower than that of exogenous stimulation in reverse saccade experiment;in memory-oriented saccade experiment, the ability of adult ADHD patients to produce and maintain endogenous saccade was not significantly lower than that of normal subjects;in visual-oriented saccade experiment, the ability of adult ADHD to produce and maintain exogenous saccades was significantly better than that of normal subjects. Therefore, the level of response of adult ADHD from endogenous stimuli is indeed lower than that produced by exogenous stimuli. Adult ADHD is susceptible to exogenous visual interference and is more likely to be caused by excessive levels of response from exogenous stimuli.