肠外营养支持联合HA280血液灌流治疗腹型过敏性紫癜临床研究

Clinical study of parenteral nutrition support combined with HA280 hemoperfusion in the treatment of children with abdominal allergic purpura

目的:探讨肠外营养支持联合HA280血液灌流治疗腹型过敏性紫癜患儿的临床效果。方法:选择腹型过敏性紫癜患儿96例,按照患儿的出生日期单日、双日分为对照组(n=48)和治疗组(n=48)。对照组患儿给予常规治疗,治疗组患儿在对照组治疗方法基础上进行血液灌流治疗,对比两组治疗期间糖皮质激素使用量、消化道症状持续时间、皮疹持续和住院时间。对比两组治疗前后的氧化应激指标变化情况。对比两组治疗前后的炎性因子变化情况。对比两组的临床治疗效果。对比两组治疗过程中的不良反应。结果:治疗组治疗期间糖皮质激素使用量、消化道症状持续时间、皮疹持续时间和住院时间均短于对照组(t=10.895、8.626、4.517、6.718,P<0.05)。经过治疗后,两组的血清丙二醛含量均降低,超氧化物歧化酶均增高(t=6.004,-3.292、11.405、-5.432,P<0.05),治疗后组间比较,治疗组丙二醛低于对照组,超氧化物歧化酶高于对照组(t=4.830、-2.277,P<0.05);两组的TNF-α、IL-6均降低(t=11.750、26.782、13.553、30.166,P<0.05),组间比较,试验组的TNF-α、IL-6低于对照组(t=4.872、4.878,P<0.05),试验组治疗效果优于对照组(Z=1.799,P<0.05);两组各项不良反应的发生率数据差异均不具有统计学意义(χ^2=1.786、1.227、0.490、2.567、2.700,P>0.05)。结论:使用肠外营养支持联合HA280血液灌流治疗腹型过敏性紫癜患儿,可以有效控制患儿的症状,缩短住院时间,改善氧化应激与炎性反应指标,安全性良好。

Objective:To investigate the clinical effect of parenteral nutrition support combined with HA280 hemoperfusion in the treatment of children with abdominal allergic purpura.Methods:Ninety-six children with abdo minal allergic purpura were enrolled and divided into control group(n=48)and treatment group(n=48)according to the date of birth.The control group was treated with routine treatment,and the treatment group were treated with blood perfusion on the basis of the control group.The dosage of glucocorticoid during the treatment period,the duration of gastrointestinal symptoms,the duration of rash,and the length of hospital stay were compared between the two groups.The changes of oxidative stress indexes and inflammatory factors before and after treatment were compared between the two groups.The clinical effect and adverse reactions of the two groups were compared.Results:The dosage of glucocorticoid during the treatment period,the duration of gastrointestinal symptoms,the duration of rash,and the length of hospital stay in the treatment group were shorter than those in the control group(t=10.895,8.626,4.517,6.718,P<0.05).After treatment,the serum malondialdehyde content was decreased and the superoxide dismutase was increased in both groups(t=6.004,-3.292,11.405,-5.432,P<0.05).In the comparison between the two groups after treatment,the malondialdehyde in the treatment group was lower than that in the control group,and the superoxide dismutase was higher than that in the control group(t=4.830,-2.777,P<0.05).After treatment,TNF-αand IL-6 were decreased in both groups(t=11.750,26.782,13.553,30.166,P<0.05).In the comparison between the two groups after treatment,TNF-αand IL-6 in the treatment group were lower than those in the control group(t=4.872,4.878,P<0.05).The therapeutic effect of the treatment group was better than that of the control group(Z=1.799,P<0.05).There was no statistically significant difference in the incidence of adversereactions between the two groups(χ^2=1.786,1.227,0.490,2.567,2.700,P>0.05).Conclusion:Parenteral nutrition support combined with HA280 hemoperfusion in the treatment of children with abdominal allergic purpura can effectively control the symptoms of children,shorten hospital stay,improve oxidative stress and inflammatory response indicators,and have good safety.