升血灵颗粒联合右旋糖酐铁口服液治疗小儿营养性缺铁贫血的疗效观察

Clinical observation on Shengxueling Granules combined with Iron Dextran Oral Solution in treatment of nutritional iron deficiency anemia in children

目的观察升血灵颗粒联合右旋糖酐铁口服液治疗小儿营养性缺铁贫血的临床效果。方法2017年5月-2019年5月郑州大学附属儿童医院治疗的小儿营养性缺铁贫血143例,将患儿随机分成对照组(n=72)和治疗组(n=71)。对照组患儿口服右旋糖酐铁口服液,10 mL/次,1次/d。治疗组在对照组用药基础上口服升血灵颗粒,一岁至三岁患儿10 g/次,三岁以上患儿15 g/次,3次/d。两组患儿均连续治疗30 d。观察两组患儿的临床疗效,比较两组临床症状消失时间、红细胞血红蛋白平均浓度(MCHC)、平均红细胞容积(MCV)、血清铁(SI)、血红蛋白(Hb)。结果治疗后,对照组和治疗组的总有效率分别是77.78%、92.96%,两组比较差异有统计学意义(P<0.05)。和治疗前比较,治疗后两组患儿MCHC、MCV、SI和Hb水平均显著增高(P<0.05);且治疗后治疗组患儿MCHC、MCV、SI和Hb水平显著高于对照组,两组比较差异有统计学意义(P<0.05)。经过治疗,治疗组临床症状消失时间显著短于对照组,两组比较差异有统计学意义(P<0.05)。结论升血灵颗粒联合右旋糖酐铁口服液治疗小儿营养性缺铁贫血具有较好的临床疗效,可有效提高机体血红蛋白和血清铁水平,调节铁代谢和红细胞状况,促进患儿恢复,具有较好的临床推广应用。

Objective To observe the clinical effect of Shengxueling Granules combined with Iron Dextran Oral Solution in treatment of nutritional iron deficiency anemia in children.Methods 143 Children with nutritional iron deficiency anemia treated in Children’s Hospital Affiliated to Zhengzhou University from May 2017 to May 2019 were randomly divided into control group(n=72)and treatment group(n=71).The children in control group were po administered with Iron Dextran Oral Solution,10 mL/time,once daily.The children in treatment group were po administered with Shengxueling Granules on the basis of the control group,aged one to three years old received 10 g/time,and children over three years old received 15 g/time,3 times daily.All patients were treated for 30 days.The clinical efficacy in two groups was observed.After treatment,the disappearance time of clinical symptoms,MCHC,MCV,SI,and Hb were compared.Results The total effective rate was 77.78%in the control group and 92.96%in the treatment group,and there were differences between two groups(P<0.05).After treatment,MCHC,MCV,SI and Hb levels were significantly higher in the two groups than before treatment(P<0.05).After treatment,MCHC,MCV,SI and Hb levels in the treatment group were significantly higher than those in the control group,and there were differences between two groups(P<0.05).After treatment,the disappearance time of clinical symptom in the treatment group was significantly shorter than that in the control group,and the difference between the two groups was statistically significant(P<0.05).Conclusion Shengxueling Granules combined with Iron Dextran Oral Solution has good clinical effect in treatment of nutritional iron deficiency anemia in children,and can effectively improve hemoglobin and serum iron levels,and also can regulate iron metabolism and red blood cell status,and promote the recovery of children,which has a certain clinical application value.