富血小板血浆(PRP)联合点阵疗法治疗雄激素源性脱发的临床观察

Clinical efficacy of platelet-rich plasma(PRP)combined with androgen-induced hair loss

目的观察富血小板血浆(PRP)联合点阵疗法治疗雄激素源性脱发的疗效及安全性。方法采用随机对照方法,纳入90例男性雄激素源性脱发患者,随机分为联合组、PRP组、非那雄胺组,各30例,非那雄胺组采用口服非那雄胺治疗,PRP组采用PRP外用+口服非那雄胺治疗,联合组采用PRP外用+点阵疗法+口服非那雄胺治疗,观察治疗前后受试者脱发及头皮油腻、瘙痒等症状改善情况评价临床疗效,监测血液、尿液常规及肝肾功能等指标评价安全性。结果经治疗后,联合组有效率93.33%,PRP组76.67%,非那雄胺组66.67%,三组有效率具有显著差异(P <0.05),联合组疗效优于PRP组,优于非那雄胺组;联合组1例、PRP组3例受试者在治疗中出现轻微肌肤刺痛、红斑,予冰敷处理后症状消失;PRP组2例受试者出现少量红色丘疹,原因为肌肤过感,给予抗敏治疗后缓解;三组患者均未出现瘢痕或者感染,血液、尿液常规及肝肾功检测均未出现异常。结论富血小板血浆联合点阵疗法对雄激素源性脱发患者临床疗效显著,安全性高,值得推广应用。

Objective To the safety and effectiveness of platelet-rich plasma(PRP)combined with androgen-induced alopecia.Methods In this study,a randomized controlled method was adopted.A total of 90 male androgen-induced alopecia cases were included.According to the random principle,they were divided into 30 cases in the combination group,30 cases in the PRP group,30 cases in the finasteride group,and all three groups received oral finasteride.Amine tablets,combination platelet-rich plasma(PRP),2940nm dot matrix,compared with PRP group platelet-rich plasma(PRP),5%topical,finasteride group,oral finasteride alone,before and after treatment Follow up and fill in the corresponding observation scale,record adverse reactions,monitor blood,urine routine,liver and kidney function,and explore the clinical efficacy of treatment of androgenetic alopecia.Results TThe combination group is effective in treating male androgen-induced alopecia,and the effect of the PRP group and the finasteride group is different(P<0.05).There are significant differences between the three groups before and after treatment(P<0.05).The group was better than the finasteride group.Conclusion The combination group is effective in treating male androgen-induced alopecia,and the effect of the PRP group and the finasteride group is different(P<0.05).There are significant differences between the three groups before and after treatment(P<0.05).The group was better than the finasteride group.