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单端孢霉烯族毒素的产生及分子调控机制 被引量:9

Recent advances on trichothece mycotoxins: their biosynthesis and regulation
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摘要 禾谷镰刀菌复合种(Fusarium graminearum species complex,FGSC)引起的赤霉病是小麦生产上危害最为严重的病害之一。赤霉病除了造成减产外,感病籽粒中含有多种镰刀菌毒素,如单端孢霉烯族的呕吐毒素,可引起人畜中毒和重大疾病,给食品安全构成严重威胁。过去20年,随着禾谷镰刀菌全基因组序列的公布和遗传转化体系的成熟,禾谷镰刀菌Fusarium graminearum的功能基因组学的研究取得了较大进展,单端孢霉烯族毒素的产生、调控机制及网络研究成为热点。本文综述国内外单端孢霉烯族毒素的生物合成和分子调控机制,包括合成基因簇及决定不同产毒化学型的基因、产毒调控元件、环境因子调控产毒的分子机制,可为小麦抗赤霉病的育种提供新思路,为新型药剂的研发提供分子靶标,为赤霉病的持续防控和毒素污染的有效治理提供理论依据。 Fusarium graminearum species complex(FGSC) is the major causal agent of Fusarium head blight(FHB) on wheat and many other small grain cereals worldwide, causing yield losses, reducing grain quality due to contamination of mycotoxin, and seriously threatening food safety. Over the last two decades, with the publication of the F. graminearum genome sequence as well as the establishment of genetic transformation system of the fungus, significant progresses for gene function studies and a more comprehensive understanding for pathogenesis and mycotoxin biosynthesis regulatory mechanism of the fungs have been achieved. In this paper, recent advances on Fusarium mycotoxin biosynthesis and its regulatory mechanisms, including biosynthetic gene cluster, regulatory elements, and epigenetic modification for mycotoxin regulation are reviewed and summarized.
作者 蒋翊宸 刘馨 方欣 冯建茹 李露 徐剑宏 史建荣 JIANG Yi-Chen;LIU Xin;FANG Xin;FENG Jian-Ru;LI Lu;XU Jian-Hong;SHI Jian-Rong(College of Food Sciences,Xizang Agriculture and Animal Husbandry College,Linzhi,Xizang 860000,China;Institute of Food Safety and Nutrition,Jiangsu Academy of Agricultural Sciences,Nanjing,Jiangsu 210014,China;School of Food and Biological Engineering,Jiangsu University,Zhenjiang,Jiangsu 212013,China;School of Chemistry and Life Sciences,Nanjing University Jinling College,Nanjing,Jiangsu 210089,China)
出处 《菌物学报》 CAS CSCD 北大核心 2020年第3期521-538,共18页 Mycosystema
基金 国家自然科学基金(31772118) 江苏省自然科学基金(BK20181246) 江苏省农业科技自主创新项目(CX(19)3004)。
关键词 单端孢霉烯 禾谷镰刀菌 基因簇 化学型 调控机制 Trichothecenes Fusarium graminearum gene cluster chemotypes regulation mechanisms
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