先天性甲状腺功能减低症患儿焦虑抑郁状况

Investigation of anxiety and depression in children with congenital hypothyroidism

目的先天性甲状腺功能减低症需长期服药,严重影响患儿心理健康,本研究探讨患儿焦虑抑郁状况及其影响因素。方法选取2016-01-01-2018-12-31郑州大学附属儿童医院收治的102例先天性甲状腺功能减低症患儿纳入病例组,选取同期在本院进行健康体检的同龄儿童80名作为对照组,应用儿童焦虑性情绪障碍筛查表及儿童抑郁障碍自评量表对受访者焦虑、抑郁状况进行调查。结果病例组焦虑障碍比例为42.16%,高于对照组的28.75%,但差异无统计学意义,χ^2=3.486,P>0.05;病例组抑郁障碍比例为21.57%,高于对照组的11.25%,但差异无统计学意义,χ^2=3.378,P>0.05。病例组躯体化/惊恐评分为(6.40±1.73)分,高于对照组的(3.74±1.70)分,t=10.369,P<0.05;学校恐怖评分为(3.68±1.88)分,高于对照组的(1.28±0.65)分,t=12.010,P<0.05;社交恐怖评分为(7.52±2.31)分,高于对照组的(4.33±2.11)分,t=9.708,P<0.05。对照组儿童抑郁障碍自评量表评分为(22.42±5.27)分,与病例组(23.61±4.89)分比较,差异无统计学意义,t=1.560,P>0.05。周围环境(OR=1.71,P=0.02)、不适症状(OR=1.14,P=0.03)和伙伴关系(OR=2.43,P=0.03)为影响先天性甲状腺功能减低症患儿焦虑抑郁情绪的危险因素。结论先天性甲状腺功能减低症患儿较正常儿童更容易出现焦虑抑郁情绪,周围环境、不适症状和伙伴关系均会影响患儿焦虑抑郁情绪。

OBJECTIVE Congenital hypothyroidism requires long-term medication to seriously affect the mental health of children.This study explores the anxiety and depression of children and its influencing factors.METHODS A total of 102 children with congenital hypothyroidism admitted to the Children’s Hospital of Zhengzhou University from January 01,2016 to December 31,2018 were enrolled in the case group.A total of 80 healthy children of the same age who were in the hospital for the same period were selected as the control group.The anxiety and depression status of the respondents were investigated with the children anxiety emotional disorder screening scale and children depression self-rating scale.RESULTS The proportion of anxiety disorder in the case group was 42.16%,which was higher than that in the control group(28.75%),but the difference was not statistically significant,χ^2=3.486,P>0.05.The proportion of depression in the case group was 21.57%,which was higher than that of the control group(11.25%),but the difference was not statistically significant,χ^2=3.378,P>0.05.The somatization/panic score of the case group was(6.40±1.73),which was higher than that of the control group(3.74±1.70),t=10.369,P<0.05.The horror score was(3.68±1.88),which was higher than the control group(1.28±0.65),t=12.010,P<0.05.The social horror score was(7.52±2.31),which was higher than the control group(4.33±2.11),t=9.708,P<0.05.The score of the self-rating scale of depression in the control group was(22.42±5.27)points,compared with the case group(23.61±4.89),the difference was not statistically significant,t=1.560,P>0.05.Ambient environment(OR=1.71,P=0.02),discomfort(OR=1.14,P=0.03)and partnership(OR=2.43,P=0.03)were the risk factors of anxiety and depression in children with congenital hypothyroidism.CONCLUSIONS Children with congenital hypothyroidism are more likely to have anxiety and depression than normal children.The surrounding environment,discomfort and partnership will affect the anxiety and depression of the child.